Mesenchymal stem/stromal cell senescence: hallmarks, mechanisms, and combating strategies

Z Weng, Y Wang, T Ouchi, H Liu, X Qiao… - Stem Cells …, 2022 - academic.oup.com
Aging is a multifaceted and complicated process, manifested by a decline of normal
physiological functions across tissues and organs, leading to overt frailty, mortality, and …

The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine

P Kumar, S Kandoi, R Misra, S Vijayalakshmi… - Cytokine & growth factor …, 2019 - Elsevier
Abstract Mesenchymal Stem Cells (MSCs) have been shown to be a promising candidate for
cell-based therapy. The therapeutic potential of MSCs, towards tissue repair and wound …

Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing

H Lin, J Sohn, H Shen, MT Langhans, RS Tuan - Biomaterials, 2019 - Elsevier
Bone has well documented natural healing capacity that normally is sufficient to repair
fractures and other common injuries. However, the properties of bone change throughout …

Mesenchymal stem cell therapy: hope for patients with systemic lupus erythematosus

A Li, F Guo, Q Pan, S Chen, J Chen, H Liu… - Frontiers in …, 2021 - frontiersin.org
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Although previous
studies have demonstrated that SLE is related to the imbalance of cells in the immune …

The heterogeneity of mesenchymal stem cells: An important issue to be addressed in cell therapy

J Li, Z Wu, L Zhao, Y Liu, Y Su, X Gong, F Liu… - Stem Cell Research & …, 2023 - Springer
With the continuous improvement of human technology, the medical field has gradually
moved from molecular therapy to cellular therapy. As a safe and effective therapeutic tool …

Experimental strategies of mesenchymal stem cell propagation: adverse events and potential risk of functional changes

K Drela, L Stanaszek, A Nowakowski… - Stem cells …, 2019 - Wiley Online Library
Mesenchymal stem cells (MSCs) are attractive candidates for cell‐based tissue repair
approaches. Hundreds of clinical trials using MSCs have been completed and many others …

The cytokine network in acute myeloid leukemia

M Luciano, PW Krenn, J Horejs-Hoeck - Frontiers in immunology, 2022 - frontiersin.org
Acute myeloid leukemia (AML) is a highly heterogeneous malignancy of the blood and bone
marrow, characterized by clonal expansion of myeloid stem and progenitor cells and rapid …

Mesenchymal stromal cell senescence in haematological malignancies

N Plakhova, V Panagopoulos, K Vandyke… - Cancer and Metastasis …, 2023 - Springer
Acute myeloid leukaemia (AML), chronic lymphocytic leukaemia (CLL), and multiple
myeloma (MM) are age-related haematological malignancies with defined precursor states …

[HTML][HTML] Mesenchymal stem cell senescence during aging: From mechanisms to rejuvenation strategies

X Jiang, W Li, L Ge, M Lu - Aging and disease, 2023 - ncbi.nlm.nih.gov
In cell transplantation therapy, mesenchymal stem cells (MSCs) are ideal seed cells due to
their easy acquisition and cultivation, strong regenerative capacity, multi-directional …

Inflammatory signaling pathways in preleukemic and leukemic stem cells

S Hemmati, T Haque, K Gritsman - Frontiers in oncology, 2017 - frontiersin.org
Hematopoietic stem cells (HSCs) are a rare subset of bone marrow cells that usually exist in
a quiescent state, only entering the cell cycle to replenish the blood compartment, thereby …