Uptake kinetics and breakthrough behavior were determined for bovine serum albumin
(BSA) and α-chymotrypsinogen (αCHY) in new polymeric ion-exchange media based on …

Physical characteristics critical to chromatography including geometric porosity and
tortuosity within the packed column were analysed based upon three dimensional …

It is well known that packing non-uniformity may cause peak asymmetry and limit the
performance of packed-bed chromatographic columns. However, understanding of the …

BACKGROUND Poorly packed chromatography columns are known to reduce drastically
the column efficiency and produce broader peaks. Controlled bed compression has been …

X-ray computed tomography has been demonstrated to be capable of imaging 1 mL (5 mm
diameter, 50 mm height) chromatography packed beds under compression, visualising the …

Experimental data are given for the solid pressure distributions in chromatography columns
of various column aspect ratios packed with four types of agarose‐based resin. The loss of …

This paper details the advancements made in the modeling of open column and packed bed
pressure-flow. The theoretical description is a one-dimensional elasticity model. By …

Preparative packed‐bed chromatography using polymer‐based, compressible, porous
resins is a powerful method for purification of macromolecular bioproducts. During …

The packing of compressible biochromatographic resins at large scale suffers from a poor
understanding of how column packing method, resin properties, and column geometry …

The common method for purification of macromolecular bioproducts is preparative packed‐
bed chromatography using polymer‐based, compressible, viscoelastic resins. Because of a …