All mucosal surfaces must deal with the challenge of exposure to the outside world. The
urothelium is a highly specialized layer of stratified epithelial cells lining the inner surface of …

The urothelium, which lines the renal pelvis, ureters, urinary bladder, and proximal urethra,
forms a high-resistance but adaptable barrier that surveils its mechanochemical …

Urinary tract infection is among the most common infections worldwide, typically studied in
animals and cell lines with limited uropathogenic strains. Here, we assessed diverse …

Urinary tract infections (UTI) are among the most prevalent infectious diseases and the most
common cause of nosocomial infections, worldwide. Uropathogenic E. coli (UPEC) are …

Membrane polarity, defined as the asymmetric distribution of lipids and proteins in the
plasma membrane, is a critical prerequisite for the development of multicellular tissues, such …

ABSTRACT 50% of Caucasians carry a Thr300Ala variant (T300A) in the protein encoded
by the macroautophagy/autophagy gene ATG16L1. Here, we show that the T300A variant …

The epithelial junctional complex, composed of tight junctions, adherens junctions,
desmosomes, and an associated actomyosin cytoskeleton, forms the apical junctional ring …

The keratin cytoskeleton and associated desmosomes contribute to the mechanical stability
of epithelial tissues, but their organization in native bladder umbrella cells and their …

Urinary tract infection is among the most common infections worldwide, and is typically
studied in animals and cell lines with limited uropathogenic strains. Here, we assessed …

Tissue injury and inflammation may result in chronic pain, a severe debilitating disease that
is associated with great impairment of quality of life. An increasing body of evidence …