The impact of loading, unloading, ageing and injury on the human tendon

SP Magnusson, M Kjaer - The Journal of physiology, 2019 - Wiley Online Library
A tendon transfers force from the contracting muscle to the skeletal system to produce
movement and is therefore a crucial component of the entire muscle‐tendon complex and its …

Tendon structure and composition

CT Thorpe, HRC Screen - Metabolic influences on risk for tendon …, 2016 - Springer
Tendons are soft, fibrous tissues that connect muscle to bone. Their main function is to
transfer muscle generated force to the bony skeleton, facilitating movement around a joint …

A Tppp3+Pdgfra+ tendon stem cell population contributes to regeneration and reveals a shared role for PDGF signalling in regeneration and fibrosis

T Harvey, S Flamenco, CM Fan - Nature cell biology, 2019 - nature.com
Tendon injuries cause prolonged disability and never recover completely. Current
mechanistic understanding of tendon regeneration is limited. Here, we use single-cell …

Intraarticular ligament degeneration is interrelated with cartilage and bone destruction in osteoarthritis

G Schulze-Tanzil - Cells, 2019 - mdpi.com
Osteoarthritis (OA) induces inflammation and degeneration of all joint components including
cartilage, joint capsule, bone and bone marrow, and ligaments. Particularly intraarticular …

Fibrous systems as potential solutions for tendon and ligament repair, healing, and regeneration

C Rinoldi, E Kijeńska‐Gawrońska… - Advanced …, 2021 - Wiley Online Library
Tendon and ligament injuries caused by trauma and degenerative diseases are frequent
and affect diverse groups of the population. Such injuries reduce musculoskeletal …

Effect of aging on tendon biology, biomechanics and implications for treatment approaches

KYC Kwan, KWK Ng, Y Rao, C Zhu, S Qi… - International Journal of …, 2023 - mdpi.com
Tendon aging is associated with an increasing prevalence of tendon injuries and/or chronic
tendon diseases, such as tendinopathy, which affects approximately 25% of the adult …

Nanoparticle-coated sutures providing sustained growth factor delivery to improve the healing strength of injured tendons

YL Zhou, QQ Yang, L Zhang, JB Tang - Acta Biomaterialia, 2021 - Elsevier
Tendon injuries are common diseases. The healing capacity of tendon is limited due to its
special composition of extra-cellular matrix and hypocellularity and hypovascularity. The …

Tendon stem/progenitor cells and their interactions with extracellular matrix and mechanical loading

C Zhang, J Zhu, Y Zhou, BP Thampatty… - Stem cells …, 2019 - Wiley Online Library
Tendons are unique connective tissues in the sense that their biological properties are
largely determined by their tendon‐specific stem cells, extracellular matrix (ECM) …

Human subacromial bursal cells display superior engraftment versus bone marrow stromal cells in murine tendon repair

F Dyrna, P Zakko, L Pauzenberger… - … American journal of …, 2018 - journals.sagepub.com
Background: Bone marrow aspirate is a primary source for cell-based therapies with
increasing value in the world of orthopaedic surgery, especially in revision cases of tendon …

A brief history of tendon and ligament bioreactors: Impact and future prospects

NA Dyment, JG Barrett, HA Awad… - Journal of …, 2020 - Wiley Online Library
Bioreactors are powerful tools with the potential to model tissue development and disease in
vitro. For nearly four decades, bioreactors have been used to create tendon and ligament …