Evolvability is the ability of a biological system to produce phenotypic variation that is both
heritable and adaptive. It has long been the subject of anecdotal observations and …

The face of evolutionary biology is changing: from reconstructing and analysing the past to
predicting future evolutionary processes. Recent developments include prediction of …

Mutations in non-coding regulatory DNA sequences can alter gene expression, organismal
phenotype and fitness,–. Constructing complete fitness landscapes, in which DNA …

Somatic mutations acquired in healthy tissues as we age are major determinants of cancer
risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance …

In experimental evolution, laboratory-controlled conditions select for the adaptation of
species, which can be monitored in real time. Despite the current popularity of such …

Microbial experimental evolution uses controlled laboratory populations to study the
mechanisms of evolution. The molecular analysis of evolved populations enables empirical …

Species interactions drive evolution while evolution shapes these interactions. The resulting
eco-evolutionary dynamics and their repeatability depend on how adaptive mutations …

Previously, we identified long repeat sequences that are frequently associated with genome
rearrangements, including copy number variation (CNV), in many diverse isolates of the …

Epistasis can markedly affect evolutionary trajectories. In recent decades, protein-level
fitness landscapes have revealed extensive idiosyncratic epistasis among specific …

Building a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary
biology. It is difficult even when adaptive mutations are known because it is hard to …