Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome

B Lam, M Masellis, M Freedman, DT Stuss… - Alzheimer's research & …, 2013 - Springer
With increasing knowledge of clinical in vivo biomarkers and the pathological intricacies of
Alzheimer's disease (AD), nosology is evolving. Harmonized consensus criteria that …

White matter hyperintensities and longitudinal cognitive decline in cognitively normal populations and across diagnostic categories: a meta‐analysis, systematic …

AD Roseborough, L Saad, M Goodman… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction The primary aim of this paper is to improve the clinical interpretation of white
matter hyperintensities (WMHs) and provide an overarching summary of methodological …

Heterogeneity in mild cognitive impairment: Differences in neuropsychological profile and associated white matter lesion pathology

L Delano-Wood, MW Bondi, J Sacco… - Journal of the …, 2009 - cambridge.org
This study examined whether distinct neuropsychological profiles could be delineated in a
sample with Mild Cognitive Impairment (MCI) and whether white matter lesion (WML) burden …

Subcortical hyperintensities are associated with cognitive decline in patients with mild cognitive impairment

S Debette, S Bombois, A Bruandet, X Delbeuck… - Stroke, 2007 - Am Heart Assoc
Background and Purpose—It has been suggested that subcortical lesions may influence
cognitive performances at early stages of cognitive impairment but not in late stages of …

Association between white matter microstructure, executive functions, and processing speed in older adults: the impact of vascular health

HIL Jacobs, EC Leritz, VJ Williams… - Human brain …, 2013 - Wiley Online Library
Cerebral white matter damage is not only a commonly reported consequence of healthy
aging, but is also associated with cognitive decline and dementia. The aetiology of this …

White matter lesions and brain atrophy: more than shared risk factors? A systematic review

APA Appelman, LG Exalto, Y Van Der Graaf… - Cerebrovascular …, 2009 - karger.com
Background: White matter lesions (WML) and brain atrophy are often found on MRI in the
elderly. Shared vascular risk factors may be an explanation for their concomitance …

Nutrition, inflammation, and cognitive function

J Wärnberg, S Gomez‐Martinez… - Annals of the new …, 2009 - Wiley Online Library
Inflammation, particularly low‐grade chronic inflammation, appears to affect several brain
functions, from early brain development to the development of neurodegenerative disorders …

Correlating cognitive decline with white matter lesion and brain atrophy magnetic resonance imaging measurements in Alzheimer's disease

M Bilello, J Doshi, SA Nabavizadeh… - Journal of …, 2015 - content.iospress.com
Background: Vascular risk factors are increasingly recognized as risks factors for
Alzheimer's disease (AD) and early conversion from mild cognitive impairment (MCI) to …

Cortical thinning related to periventricular and deep white matter hyperintensities

SW Seo, JM Lee, K Im, JS Park, SH Kim, ST Kim… - Neurobiology of …, 2012 - Elsevier
Previous studies showed that white matter hyperintensities (WMH) are related to cognitive
decline in patients with mild cognitive impairment (MCI) or dementia. Moreover …

Differences in brain volume, hippocampal volume, cerebrovascular risk factors, and apolipoprotein E4 among mild cognitive impairment subtypes

J He, S Farias, O Martinez, B Reed… - Archives of …, 2009 - jamanetwork.com
Objectives To evaluate demographics, magnetic resonance imaging (MRI) measures, and
vascular risk among mild cognitive impairment (MCI) subtypes. Design Cross-sectional …