[HTML][HTML] Mechanisms of cell protection by heme oxygenase-1
Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into
equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive …
equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive …
Heme oxygenase-1 and anti-inflammatory M2 macrophages
Y Naito, T Takagi, Y Higashimura - Archives of biochemistry and biophysics, 2014 - Elsevier
Abstract Heme oxygenase-1 (HO-1) catalyzes the first and rate-limiting enzymatic step of
heme degradation and produces carbon monoxide, free iron, and biliverdin. HO-1, a stress …
heme degradation and produces carbon monoxide, free iron, and biliverdin. HO-1, a stress …
An extracorporeal blood-cleansing device for sepsis therapy
Here we describe a blood-cleansing device for sepsis therapy inspired by the spleen, which
can continuously remove pathogens and toxins from blood without first identifying the …
can continuously remove pathogens and toxins from blood without first identifying the …
A central role for free heme in the pathogenesis of severe sepsis
R Larsen, R Gozzelino, V Jeney, L Tokaji… - Science translational …, 2010 - science.org
Low-grade polymicrobial infection induced by cecal ligation and puncture is lethal in heme
oxygenase-1–deficient mice (Hmox1−/−), but not in wild-type (Hmox1+/+) mice. Here we …
oxygenase-1–deficient mice (Hmox1−/−), but not in wild-type (Hmox1+/+) mice. Here we …
Kynurenine is an endothelium-derived relaxing factor produced during inflammation
Control of blood vessel tone is central to vascular homeostasis. Here we show that
metabolism of tryptophan to kynurenine by indoleamine 2, 3-dioxygenase (Ido) expressed in …
metabolism of tryptophan to kynurenine by indoleamine 2, 3-dioxygenase (Ido) expressed in …
Contributions of City-Specific Fine Particulate Matter (PM2.5) to Differential In Vitro Oxidative Stress and Toxicity Implications between Beijing and Guangzhou of …
Growing literature has documented varying toxic potencies of source-or site-specific fine
particulate matter (PM2. 5), as opposed to the practice that treats particle toxicities as …
particulate matter (PM2. 5), as opposed to the practice that treats particle toxicities as …
Carbon monoxide‐releasing molecules (CO‐RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264. 7 murine macrophages
P Sawle, R Foresti, BE Mann… - British journal of …, 2005 - Wiley Online Library
1 The enzyme heme oxygenase‐1 (HO‐1) is a cytoprotective and anti‐inflammatory protein
that degrades heme to produce biliverdin/bilirubin, ferrous iron and carbon monoxide (CO) …
that degrades heme to produce biliverdin/bilirubin, ferrous iron and carbon monoxide (CO) …
Therapeutic applications of carbon monoxide-releasing molecules
R Motterlini, BE Mann, R Foresti - Expert opinion on investigational …, 2005 - Taylor & Francis
Carbon monoxide (CO), which is formed in mammalian cells through the oxidation of haem
by the enzyme haem oxygenase, actively participates in the regulation of key intracellular …
by the enzyme haem oxygenase, actively participates in the regulation of key intracellular …
Vasoactive properties of CORM‐3, a novel water‐soluble carbon monoxide‐releasing molecule
Carbon monoxide (CO), one of the end products of heme catabolism by heme oxygenase,
possesses antihypertensive and vasodilatory characteristics. We have recently discovered …
possesses antihypertensive and vasodilatory characteristics. We have recently discovered …
Heme oxygenase and the cardiovascular–renal system
NG Abraham, A Kappas - Free Radical Biology and Medicine, 2005 - Elsevier
Heme oxygenase (HO) has been shown to be important for attenuating the overall
production of reactive oxygen species (ROS) through its ability to degrade heme and to …
production of reactive oxygen species (ROS) through its ability to degrade heme and to …