Circular RNAs (circRNAs) are a class of endogenous RNAs characterized by a covalent
loop structure. In comparison to other types of RNAs, the abundance of circRNAs is relatively …

Circular RNA s (circ RNA s) comprise an emerging new class of endogenous RNA s
expressed abundantly by the eukaryotic transcriptome. They are characterized by a …

Background In recent years, circular RNAs (circRNAs), a new star of non-coding RNA, have
been emerged as vital regulators and gained much attention for involvement of initiation and …

The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …

Emerging evidence indicates that the abnormal expression of miRNAs involves in the
evolution and progression of various human complex diseases. Identifying disease-related …

Non-coding RNAs (ncRNAs) are regulators of intracellular and intercellular signaling in
breast cancer. ncRNAs modulate intracellular signaling to control diverse cellular processes …

Purpose: There is a quest for novel noninvasive diagnostic markers for the detection of
breast cancer. The goal of this study is to identify circulating microRNA (miRNA) signatures …

The ability to reprogram the transcriptional circuitry by remodeling the three-dimensional
structure of the genome is exploited by cancer cells to promote tumorigenesis. This …

Abstract Background Circular RNAs are a class of endogenous RNAs with various functions
in eukaryotic cells. Worthy of note, circular RNAs play a critical role in cancer. Currently …