Purpose Triple-negative breast cancer (TNBC) is a heterogeneous group of tumors
comprising various breast cancers simply defined by the absence of estrogen receptor …

Gene-expression profiling has had a considerable impact on our understanding of breast
cancer biology, and more recently on clinical care. Two statistical approaches underlie these …

Cancer cells respond to various stressful conditions through the dynamic regulation of RNA
m6A modification. Doxorubicin is a widely used chemotherapeutic drug that induces DNA …

Objectives Physical inactivity and sedentary behaviour are associated with higher breast
cancer risk in observational studies, but ascribing causality is difficult. Mendelian …

BACKGROUND: Taxanes are established in the treatment of metastatic breast cancer (MBC)
and early breast cancer (EBC) as potent chemotherapy agents. However, their therapeutic …

Introduction EndoPredict (EP) is an RNA-based multigene test that predicts the likelihood of
distant recurrence in patients with estrogen receptor-positive (ER+), human epidermal …

Purpose: Recent studies demonstrate that addition of neoadjuvant (NA) carboplatin to
anthracycline/taxane chemotherapy improves pathologic complete response (pCR) in triple …

Triple negative breast cancer (TNBC) is a heterogeneous disease at the molecular,
pathologic and clinical levels. To stratify TNBCs, we determined microRNA (miRNA) …

MCL1, which encodes the antiapoptotic protein MCL1, is among the most frequently
amplified genes in human cancer. A chemical genomic screen identified compounds …

Neoadjuvant chemotherapy provides a means both of improving subsequent surgical
intervention and of testing novel therapies or combinations. Historically, triple-negative …