Comorbidities are a hallmark of stroke that both increase the incidence of stroke and worsen
outcome. Hypertension is prevalent in the stroke population and the most important …

The blood vessels of the brain are lined with endothelial cells and it has been long known
that these help to regulate blood flow to the brain. However, there is increasing evidence …

Faraci, Frank M., and Donald D. Heistad. Regulation of the Cerebral Circulation: Role of
Endothelium and Potassium Channels. Physiol. Rev. 78: 53–97, 1998.—Several new …

Background Experimental data from normotensive and hypertensive animals indicate that
aging is associated with impaired endothelium-dependent relaxations to acetylcholine, and …

First published in 1990: The Endothelium: Modulator of Cardiovascular Function takes a
comprehensive look at the role of the endothelium in cardiovascular control in health and …

The impact of vascular risk factors on cognitive function has garnered much interest in recent
years. The appropriate distribution of oxygen, glucose, and other nutrients by the cerebral …

When angina occurs in patients with hypertension, it is usually attributed to coronary artery
disease or left ventricular hypertrophy. To determine the contribution of coronary …

Background After focal brain ischemia, leukocytes adhere to the perturbed endothelium and
are believed to aggravate reperfusion injury. Although ischemia-induced upregulation of …

The endothelium not only mediates relaxation but is a source of contracting factors.
Endothelium-dependent contractions are elicited by physical and chemical stimuli (ie …

Endothelial cells exert an enormous influence on blood vessels throughout the circulation,
but their impact is particularly pronounced in the brain. New concepts have emerged …