[HTML][HTML] Breast cancer molecular stratification: from intrinsic subtypes to integrative clusters
HG Russnes, OC Lingjærde, AL Børresen-Dale… - The American journal of …, 2017 - Elsevier
Breast carcinomas can be stratified into different entities based on clinical behavior,
histologic features, and/or by biological properties. A classification of breast cancer should …
histologic features, and/or by biological properties. A classification of breast cancer should …
Patterns of genomic instability in breast cancer
Breast cancer is one of the most common cancers affecting women. Despite significant
improvements in overall survival, it remains a significant cause of death worldwide. Genomic …
improvements in overall survival, it remains a significant cause of death worldwide. Genomic …
Molecular landmarks of tumor hypoxia across cancer types
Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia.
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …
[HTML][HTML] PD-L1 protein expression in breast cancer is rare, enriched in basal-like tumours and associated with infiltrating lymphocytes
HR Ali, SE Glont, FM Blows, E Provenzano… - Annals of …, 2015 - Elsevier
Background Expression of programmed death ligand 1 (PD-L1) in solid tumours has been
shown to predict whether patients are likely to respond to anti-PD-L1 therapies. To estimate …
shown to predict whether patients are likely to respond to anti-PD-L1 therapies. To estimate …
Sex differences in cancer driver genes and biomarkers
Cancer differs significantly between men and women; even after adjusting for known
epidemiologic risk factors, the sexes differ in incidence, outcome, and response to therapy …
epidemiologic risk factors, the sexes differ in incidence, outcome, and response to therapy …
Age influences on the molecular presentation of tumours
Cancer is often called a disease of aging. There are numerous ways in which cancer
epidemiology and behaviour change with the age of the patient. The molecular bases for …
epidemiology and behaviour change with the age of the patient. The molecular bases for …
Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome
Background Breast cancer is a heterogeneous disease at the clinical and molecular level. In
this study we integrate classifications extracted from five different molecular levels in order to …
this study we integrate classifications extracted from five different molecular levels in order to …
Sequencing structural variants in cancer for precision therapeutics
G Macintyre, B Ylstra, JD Brenton - Trends in Genetics, 2016 - cell.com
The identification of mutations that guide therapy selection for patients with cancer is now
routine in many clinical centres. The majority of assays used for solid tumour profiling use …
routine in many clinical centres. The majority of assays used for solid tumour profiling use …
Somatic BRCA1/2 Recovery as a Resistance Mechanism After Exceptional Response to Poly (ADP-ribose) Polymerase Inhibition
Purpose Durable and long-term responses to the poly (ADP-ribose) polymerase inhibitor
olaparib are observed in patients without BRCA1/2 mutations. However, beyond BRCA1/2 …
olaparib are observed in patients without BRCA1/2 mutations. However, beyond BRCA1/2 …
[HTML][HTML] Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer: a systematic review and economic analysis.
S Harnan, P Tappenden, K Cooper… - Health Technology …, 2019 - ncbi.nlm.nih.gov
BACKGROUND Breast cancer and its treatment can have an impact on health-related
quality of life and survival. Tumour profiling tests aim to identify whether or not women need …
quality of life and survival. Tumour profiling tests aim to identify whether or not women need …