Fitness of cells is dependent on protein homeostasis which is maintained by cooperative
activities of protein chaperones and proteolytic machinery. Upon encountering protein …

Heat shock proteins (HSPs) are a large molecular chaperone family classified by their
molecular weights, including HSP27, HSP40, HSP60, HSP70, HSP90, and HSP110. HSPs …

The human HSP70 family is a type of heat shock protein (HSP), consisting of 13 members
encoded by the HSPA genes. HSPs play important roles in regulating cellular responses …

Background The HSP70 family of heat shock protein plays a critical role in protein synthesis
and transport to maintain protein homeostasis. Several studies have indicated that HSP70s …

Identification of new molecular targets is needed for the treatment of colorectal cancer
(CRC). Methylenetetrahydrofolate dehydrogenase 1 like (MTHFD1L), an enzyme in the …

Background Encouraged by the goal of developing an effective treatment strategy for
prostate cancer, this study explored the mechanism involved in metformin-mediated …

Heat shock proteins HSPA1/Hsp70α and HSP90AA1/Hsp90α are crucial for cancer growth
but their expression pattern in colorectal polyps or whether they can be modulated by …

Deregulation of E3 ubiquitin ligases is intimately implicated in breast cancer pathogenesis
and progression, but the underlying mechanisms still remain elusive. Here we report that …

Colorectal cancer (CRC) is one of the most common malignancies in the world. Despite
intensive advances in diagnosis and treatment of CRC, it is yet one of the leading cause of …

Deposition, remodeling, and signaling of the extracellular matrix facilitate tumor growth and
metastasis. Here, we demonstrated that an enzyme, collagen prolyl 4-hydroxylase, alpha …