Sensory neurons with cell bodies situated in dorsal root ganglia convey information from
external or internal sites of the body such as actual or potential harm, temperature or muscle …

Pain is a complex multidimensional concept that facilitates the initiation of the signaling
cascade in response to any noxious stimuli. Action potential generation in the peripheral …

Purpose To test long-term ocular toxicity and analgesic/anti-inflammatory efficacy of two
novel ocular formulations of neurokinin 1 receptor (NK1R) antagonist Aprepitant. Methods …

Spinal cord injury (SCI) leads to disruption of the blood–spinal cord barrier, hemorrhage,
and tissue edema, which impair blood circulation and induce ischemia. Angiogenesis after …

Multiple sclerosis (MS) is a multifaceted, complex and chronic neurological disease that
leads to motor, sensory and cognitive deficits. MS symptoms are unpredictable and …

Purpose: The purpose of this study was to test the role of substance P (SP) and its receptor
neurokinin 1 (NK1R) on ocular surface pain. Methods: Eight-week-old C57BL6/N (wild type …

Complex regional pain syndrome type-I (CRPS-I) is a chronic painful condition resulting
from trauma. Bradykinin (BK) is an important inflammatory mediator required in acute and …

Chronic inflammation in fibroblast-like synoviocytes (FLSs) induced by pro-inflammatory
cytokines such as TNF-α plays a key role in the pathogenesis of rheumatoid arthritis (RA) …

The nervous system is engaged by infection, indirectly through inflammatory cascades or
directly, by bacterial attack on nerve cells. Here we identify a neuro-epithelial activation loop …

Background Chemotherapy-induced neuropathic pain is a disabling condition following
cancer treatment. Vincristine has more neurotoxicity than other vinca alkaloid agents. This …