Glycosylation produces a diverse and abundant repertoire of glycans, which are collectively
known as the glycome. Glycans are one of the four fundamental macromolecular …

Galectins, β‐galactoside‐binding animal lectins, are differentially expressed by various
immune cells as well as a wide range of other cell types. Extracellularly, galectins are able to …

Through their specific interactions with proteins, cellular glycans play key roles in a wide
range of physiological and pathological processes. One of the main goals of research in the …

Eukaryotic cells have a highly evolved system of protein secretion, and dysfunction in this
pathway is associated with many diseases including cancer, infection, metabolic disease …

In the past decade, increasing efforts have been devoted to the study of galectins, a family of
evolutionarily conserved glycan-binding proteins with multifunctional properties. Galectins …

The expression of ABO (H) blood group antigens causes deletion of cells that generate self-
specific antibodies to these antigens but this deletion limits adaptive immunity toward …

Galectins are β‐galcotosid‐binding lectins. The function of galectins varies with their tissue‐
specific and subcellular location, and their binding to carbohydrates makes them key players …

The glycocalyx is a glycan layer found on the surfaces of host cells as well as
microorganisms and enveloped virus. Its thickness may easily exceed 50 nm. The …

Abstract A Tim-3 ligand, galectin-9 (Gal-9), modulates various functions of innate and
adaptive immune responses. In this study, we demonstrate that Gal-9 prolongs the survival …

The galectin family consists of carbohydrate (glycan) binding proteins that are expressed by
a wide variety of cells and bind to galactose-containing glycans. Galectins can be located in …