Ischemia‐reperfusion injury (IRI) has indeed been shown as a main complication of
hepatectomy, liver transplantation, trauma, and hypovolemic shock. A large number of …

The mitochondrial permeability transition pore (MPTP) is a calcium-dependent, ion non-
selective membrane pore with a wide range of functions. Although the MPTP has been …

Hypoxia plays an important role in the development of many infectious, inflammatory, and
tumor diseases. The predisposition to such disorders is mostly provided by differences in …

Currently, a new line of research on mitochondria-targeted anticancer drugs is actively
developing in the field of biomedicine and medicinal chemistry. The distinguishing features …

Background Globally, the onset and progression of multiple human diseases are associated
with mitochondrial dysfunction and dysregulation of Ca 2+ uptake dynamics mediated by the …

Hypoxia–ischemia (HI) leads to immature brain injury mediated by mitochondrial stress. If
damaged mitochondria cannot be repaired, mitochondrial permeabilization ensues, leading …

Oxygen deficiency is one of the key pathogenetic factors determining development and
severity of many diseases, including inflammatory, infectious diseases, and cancer. Lack of …

Abstract Mitochondrial calcium (Ca 2+) regulation is critically implicated in the regulation of
bioenergetics and cell fate. Ca 2+, a universal signaling ion, passively diffuses into the …

ATP is the most universal and essential energy molecule in cells. This is due to its ability to
store cellular energy in form of high‐energy phosphate bonds, which are extremely stable …

Simple Summary Diabetes mellitus as a systemic metabolic disease is one of the most
serious threats to global health in this century. Diabetic cardiomyopathy is increasingly …