Benzothiazole derivatives as effective α-glucosidase inhibitors: an insight study of structure-activity relationships and molecular targets
Z Khalifa, R Upadhyay, AB Patel - Medicinal Chemistry Research, 2024 - Springer
In treating the major metabolic disorder diabetes mellitus type-2, the α-glucosidase enzyme
inhibitors play an effective role due to their vital capability of polysaccharide hydrolyzation. A …
inhibitors play an effective role due to their vital capability of polysaccharide hydrolyzation. A …
New Hybrid Hydrazinyl Thiazole Substituted Chromones: As Potential α-Amylase Inhibitors and Radical (DPPH & ABTS) Scavengers
Current research is based on the identification of novel inhibitors of α-amylase enzyme. For
that purpose, new hybrid molecules of hydrazinyl thiazole substituted chromones 5–27 were …
that purpose, new hybrid molecules of hydrazinyl thiazole substituted chromones 5–27 were …
Synthesis and Biological Importance of 2-(thio) ureabenzothiazoles
MC Rosales-Hernández, JE Mendieta-Wejebe… - Molecules, 2022 - mdpi.com
The (thio) urea and benzothiazole (BT) derivatives have been shown to have a broad
spectrum of biological activities. These groups, when bonded, result in the 2-(thio) …
spectrum of biological activities. These groups, when bonded, result in the 2-(thio) …
New hybrid scaffolds based on hydrazinyl thiazole substituted coumarin; as novel leads of dual potential; in vitro α-amylase inhibitory and antioxidant (DPPH and …
Background: Despite many side effects associated, there are many drugs which are being
clinically used for the treatment of type-II diabetes mellitus (DM). In this scenario, there is still …
clinically used for the treatment of type-II diabetes mellitus (DM). In this scenario, there is still …
2-Mercapto benzothiazole derivatives: As potential leads for the diabetic management
Background: Results of our previous studies on antiglycation activity, and the noncytotoxicity
of 2-mercapto benzothiazoles, encouraged us to further widen our investigation towards the …
of 2-mercapto benzothiazoles, encouraged us to further widen our investigation towards the …
Facile synthesis of novel substituted aryl-thiazole (SAT) analogs via one-pot multi-component reaction as potent cytotoxic agents against cancer cell lines
In this study, twenty-five (25) substituted aryl thiazoles (SAT) 1–25 were synthesized, and
their in vitro cytotoxicity was evaluated against four cancer cell lines, MCF-7 (ER+ ve breast) …
their in vitro cytotoxicity was evaluated against four cancer cell lines, MCF-7 (ER+ ve breast) …
Synthesis of pyridinyl-benzo [d] imidazole/pyridinyl-benzo [d] thiazole derivatives and their yeast glucose uptake activity in vitro
M Khan, R Ahmad, G Rehman, N Gul… - Letters in Drug …, 2019 - ingentaconnect.com
Background: Diabetes is the primary cause of fatality and disability all over the world, in
recent past, we have reported various classes of compounds as anti-glycating agents and …
recent past, we have reported various classes of compounds as anti-glycating agents and …
Protein glycation during diabetes mellitus and the possibility of its pharmacological correction
AA Spasov, OA Solov'Eva, VA Kuznetsova - Pharmaceutical chemistry …, 2017 - Springer
Non-enzymatic interaction of reducing sugars with free amines of proteins (Maillard reaction)
leads to the formation of advanced glycation end products (AGEs) and is an important factor …
leads to the formation of advanced glycation end products (AGEs) and is an important factor …
Biology-oriented Drug Synthesis (BIODS), Structural Characterization and Bioactivities of Novel Albendazole Derivatives
Background: Albendazole is a drug, belongs to the family of benzimidazole, and used as an
anthelmintic agent in both human and veterinary medicine. It is marketed as Albenza which …
anthelmintic agent in both human and veterinary medicine. It is marketed as Albenza which …
Small synthetic molecules with antiglycation activity. Structure–activity relationship
KV Savateev, AA Spasov… - Russian Chemical …, 2022 - iopscience.iop.org
The accumulation of advanced glycation end products (AGEs) is currently considered as
one of the key factors in aging processes, the pathogenesis of late complications of diabetes …
one of the key factors in aging processes, the pathogenesis of late complications of diabetes …