Chiral molecules containing asymmetric carbon centers bonded with nitrogen are ubiquitous
in nature and also form important structural fragments in both natural and man-made …

The catalysis by primary and secondary amines of electrophilic substitution reactions in the
R-position of carbonyl compounds and related reactions via enamine intermediates is called …

Asymmetric aldol reactions are a powerful method for the construction of carbon–carbon
bonds in an enantioselective fashion. Historically this reaction has been performed in a …

Abstract The legacy of Gilbert Newton Lewis (1875–1946) pervades the lexicon of chemical
bonding and reactivity. The power of his concept of donor–acceptor bonding is evident in the …

After an initial period of validating asymmetric organocatalysis by using a wide range of
important model reactions that constitute the essential tools of organic synthesis, the time …

The enantioselective production of compounds is a central theme in current research. The
broad utility of synthetic chiral molecules as single-enantiomer pharmaceuticals, in …

We have developed direct asymmetric cross-aldol reactions that can be performed in water
without addition of organic solvents. A bifunctional catalyst with a long hydrophobic alkyl …

In the last eight years, L-proline and L-proline derivatives, such as substituted prolinamides
or pyrrolidines, have been successfully used as organocatalysts in several reactions. In this …

Methods for enantioselective C–C bond constructions via additions to imines and related
compounds are reviewed, with an emphasis on the most recent efforts involving asymmetric …

The use of simple (S)-proline as catalyst for the intermolecular direct aldol reaction at the
beginning of this century became a true milestone in the growth of organocatalysis as a …