Role of thymic stromal lymphopoietin in allergy and beyond

R Ebina-Shibuya, WJ Leonard - Nature Reviews Immunology, 2023 - nature.com
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that acts on multiple cell
lineages, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils and …

Interleukin-33 (IL-33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine

C Cayrol, JP Girard - Cytokine, 2022 - Elsevier
Abstract Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with
crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic …

Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma

M Depner, DH Taft, PV Kirjavainen, KM Kalanetra… - Nature medicine, 2020 - nature.com
Growing up on a farm is associated with an asthma-protective effect, but the mechanisms
underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural …

Race and genetic ancestry in medicine—a time for reckoning with racism

LN Borrell, JR Elhawary, E Fuentes-Afflick… - … England Journal of …, 2021 - Mass Medical Soc
Race and Genetic Ancestry in Medicine US health inequities won't be eliminated by
abandoning the use of race and ethnicity in research and clinical practice, since these …

After asthma: redefining airways diseases

ID Pavord, R Beasley, A Agusti, GP Anderson, E Bel… - The Lancet, 2018 - thelancet.com
Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …

Interleukin‐33 (IL‐33): a nuclear cytokine from the IL‐1 family

C Cayrol, JP Girard - Immunological reviews, 2018 - Wiley Online Library
Summary Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family
abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both …

Epithelial cell–derived cytokines: more than just signaling the alarm

F Roan, K Obata-Ninomiya… - The Journal of clinical …, 2019 - Am Soc Clin Investig
The epithelial cell–derived cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25
are central regulators of type 2 immunity, which drives a broad array of allergic responses …

Interleukin-33 in health and disease

FY Liew, JP Girard, HR Turnquist - Nature Reviews Immunology, 2016 - nature.com
Abstract Interleukin-33 (IL-33)—a member of the IL-1 family—was originally described as an
inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now …

The role of antioxidants in the chemistry of oxidative stress: A review

AM Pisoschi, A Pop - European journal of medicinal chemistry, 2015 - Elsevier
Abstract This Review Article is focused on the action of the reactive oxygenated species in
inducing oxidative injury of the lipid membrane components, as well as on the ability of …

Cellular and molecular mechanisms of allergic asthma

ZI Komlósi, W van de Veen, N Kovács, G Szűcs… - Molecular aspects of …, 2022 - Elsevier
Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …