Advanced situation with recombinant toxins: Diversity, production and application purposes

E Efremenko, A Aslanli, I Lyagin - International Journal of Molecular …, 2023 - mdpi.com
Today, the production and use of various samples of recombinant protein/polypeptide toxins
is known and is actively developing. This review presents state-of-the-art in research and …

Nucleic acid actions on abnormal protein aggregation, phase transitions and phase separation

JL Silva, TC Vieira, Y Cordeiro… - Current Opinion in …, 2022 - Elsevier
Liquid–liquid phase separation (LLPS) and phase transitions (PT) of proteins, which include
the formation of gel-and solid-like species, have been characterized as physical processes …

The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes

F Raguseo, Y Wang, J Li, M Petrić Howe… - Nature …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative diseases that exist on a clinico-pathogenetic spectrum, designated …

Liquid‐liquid phase separation and fibrillation of the prion protein modulated by a high‐affinity DNA aptamer

CO Matos, YM Passos, MJ do Amaral… - The FASEB …, 2020 - Wiley Online Library
Structural conversion of cellular prion protein (PrPC) into scrapie PrP (PrPSc) and
subsequent aggregation are key events associated with the onset of transmissible …

RNA as the stone guest of protein aggregation

A Louka, E Zacco, PA Temussi… - Nucleic Acids …, 2020 - academic.oup.com
The study of prions as infectious aggregates dates several decades. From its original
formulation, the definition of a prion has progressively changed to the point that many …

Temperature-dependent structural variability of prion protein amyloid fibrils

M Ziaunys, A Sakalauskas, K Mikalauskaite… - International journal of …, 2021 - mdpi.com
Prion protein aggregation into amyloid fibrils is associated with the onset and progression of
prion diseases—a group of neurodegenerative amyloidoses. The process of such aggregate …

Heterotypic interactions in amyloid function and disease

K Konstantoulea, N Louros, F Rousseau… - The FEBS …, 2022 - Wiley Online Library
Amyloid aggregation results from the self‐assembly of identical aggregation‐prone
sequences into cross‐beta‐sheet structures. The process is best known for its association …

CAPRIN1P512L causes aberrant protein aggregation and associates with early-onset ataxia

A Delle Vedove, J Natarajan, G Zanni… - Cellular and Molecular …, 2022 - Springer
CAPRIN1 is a ubiquitously expressed protein, abundant in the brain, where it regulates the
transport and translation of mRNAs of genes involved in synaptic plasticity. Here we …

[HTML][HTML] Circ-Hdgfrp3 shuttles along neurites and is trapped in aggregates formed by ALS-associated mutant FUS

E D'Ambra, T Santini, E Vitiello, S D'Uva, V Silenzi… - IScience, 2021 - cell.com
CircRNAs belong to a family of RNA molecules which are conserved in evolution, have
tissue-specific expression, and are abundant in neuronal cells. Here, we define several …

[HTML][HTML] The prion protein and its ligands: Insights into structure-function relationships

M Shafiq, S Da Vela, L Amin, N Younas… - … et Biophysica Acta (BBA …, 2022 - Elsevier
The prion protein is a multifunctional protein that exists in at least two different folding states.
It is subject to diverse proteolytic processing steps that lead to prion protein fragments some …