Clonal haematopoiesis and dysregulation of the immune system
Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …
Clonal hematopoiesis and its impact on human health
Aging is associated with increased mutational burden in every tissue studied. Occasionally,
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …
fitness-increasing mutations will arise, leading to stem cell clonal expansion. This process …
Common and rare variant associations with clonal haematopoiesis phenotypes
Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been
associated with ageing and adverse health outcomes,,,–. Here we use exome sequence …
associated with ageing and adverse health outcomes,,,–. Here we use exome sequence …
A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets
Clonal hematopoiesis of indeterminate potential (CHIP) is a common form of age-related
somatic mosaicism that is associated with significant morbidity and mortality. CHIP mutations …
somatic mosaicism that is associated with significant morbidity and mortality. CHIP mutations …
TET2-mutant clonal hematopoiesis and risk of gout
Gout is a common inflammatory arthritis caused by precipitation of monosodium urate (MSU)
crystals in individuals with hyperuricemia. Acute flares are accompanied by secretion of …
crystals in individuals with hyperuricemia. Acute flares are accompanied by secretion of …
[HTML][HTML] Clonal hematopoiesis, somatic mosaicism, and age-associated disease
MA Evans, K Walsh - Physiological Reviews, 2022 - journals.physiology.org
Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …
Clonal hematopoiesis: Mutation-specific adaptation to environmental change
MA Florez, BT Tran, TK Wathan, J DeGregori… - Cell Stem Cell, 2022 - cell.com
Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …
of genetically variant hematopoietic cells that increases exponentially with age and is …
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages
Deleterious somatic mutations in DNA methyltransferase 3 alpha (DNMT3A) and TET
mehtylcytosine dioxygenase 2 (TET2) are associated with clonal expansion of …
mehtylcytosine dioxygenase 2 (TET2) are associated with clonal expansion of …
Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis
Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In
this study, we establish that aging of the immune system, regardless of the age of the stroma …
this study, we establish that aging of the immune system, regardless of the age of the stroma …
Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated atherosclerosis and concordant macrophage phenotypes
Clonal hematopoiesis of indeterminate potential (CHIP) is defined by the presence of a
cancer-associated somatic mutation in white blood cells in the absence of overt …
cancer-associated somatic mutation in white blood cells in the absence of overt …