Making waves: New developments in toxicology with the zebrafish

KA Horzmann, JL Freeman - Toxicological Sciences, 2018 - academic.oup.com
The laboratory zebrafish (Danio rerio) is now an accepted model in toxicologic research.
The zebrafish model fills a niche between in vitro models and mammalian biomedical …

An ecotoxicological view on neurotoxicity assessment

JB Legradi, C Di Paolo, MHS Kraak… - Environmental Sciences …, 2018 - Springer
The numbers of potential neurotoxicants in the environment are raising and pose a great risk
for humans and the environment. Currently neurotoxicity assessment is mostly performed to …

Polystyrene nanoplastics (20 nm) are able to bioaccumulate and cause oxidative DNA damages in the brain tissue of zebrafish embryo (Danio rerio)

TÖ Sökmen, E Sulukan, M Türkoğlu, A Baran… - Neurotoxicology, 2020 - Elsevier
Nano-sized plastic particles formed from both daily use plastics and its debris have become
a potential health and environmental problem due to features such as transportation through …

Advancements in zebrafish applications for 21st century toxicology

GR Garcia, PD Noyes, RL Tanguay - Pharmacology & therapeutics, 2016 - Elsevier
The zebrafish model is the only available high-throughput vertebrate assessment system,
and it is uniquely suited for studies of in vivo cell biology. A sequenced and annotated …

Oxidative stress induced antioxidant and neurotoxicity demonstrated in vivo zebrafish embryo or larval model and their normalization due to morin showing …

PK Issac, A Guru, M Velayutham, R Pachaiappan… - Life sciences, 2021 - Elsevier
Aims The study examined that morin as possible antioxidant and neuroprotective due to
oxidative stress (H 2 O 2) in zebrafish larval model. Materials and methods Zebrafish larvae …

[HTML][HTML] Recommendation on test readiness criteria for new approach methods (NAM) in toxicology: exemplified for developmental neurotoxicity (DNT)

A Bal-Price, HT Hogberg, KM Crofton, M Daneshian… - Altex, 2018 - ncbi.nlm.nih.gov
Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

Zebrafish as an animal model for drug discovery in Parkinson's disease and other movement disorders: a systematic review

RL Vaz, TF Outeiro, JJ Ferreira - Frontiers in neurology, 2018 - frontiersin.org
Movement disorders can be primarily divided into hypokinetic and hyperkinetic. Most of the
hypokinetic syndromes are associated with the neurodegenerative disorder Parkinson's …

Using zebrafish in systems toxicology for developmental toxicity testing

Y Nishimura, A Inoue, S Sasagawa… - Congenital …, 2016 - Wiley Online Library
With the high cost and the long‐term assessment of developmental toxicity testing in
mammals, the vertebrate zebrafish has become a useful alternative model organism for high …

Zebrafish get connected: investigating neurotransmission targets and alterations in chemical toxicity

KA Horzmann, JL Freeman - Toxics, 2016 - mdpi.com
Neurotransmission is the basis of neuronal communication and is critical for normal brain
development, behavior, learning, and memory. Exposure to drugs and chemicals can alter …

Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish

KA Jarema, DL Hunter, RM Shaffer, M Behl… - Neurotoxicology and …, 2015 - Elsevier
As polybrominated diphenyl ethers are phased out, numerous compounds are emerging as
potential replacement flame retardants for use in consumer and electronic products. Little is …