ISPAD Clinical Practice Consensus Guidelines 2022: Type 2 diabetes in children and adolescents

AS Shah, PS Zeitler, J Wong, AS Pena… - Pediatric …, 2022 - Wiley Online Library
Since the 2018 ISPAD guidelines on this topic, follow‐up of large cohorts from around the
globe have continued informing the current incidence and prevalence of co‐morbidities and …

Efficacy and safety of the SGLT2 inhibitor empagliflozin versus placebo and the DPP-4 inhibitor linagliptin versus placebo in young people with type 2 diabetes …

LM Laffel, T Danne, GJ Klingensmith… - The lancet Diabetes & …, 2023 - thelancet.com
Background The incidence of type 2 diabetes in young people is increasing, but treatments
remain limited. We aimed to assess the efficacy and safety of an empagliflozin dosing …

Childhood Obesity, Diabetes, and Cardiovascular Disease Risk

M Salama, B Balagopal, I Fennoy… - The Journal of Clinical …, 2023 - academic.oup.com
This mini-review aims to briefly summarize the pathophysiology of childhood obesity, type 2
diabetes mellitus (T2DM), and cardiovascular disease (CVD) risk in children and …

Dapagliflozin or saxagliptin in pediatric type 2 diabetes

N Shehadeh, T Barrett, P Galassetti, C Karlsson… - NEJM …, 2023 - evidence.nejm.org
Background Incidence of type 2 diabetes (T2D) in children and adolescents is increasing,
but treatment options are limited. Methods This was a 26-week, phase 3 trial with a 26-week …

Efficacy and safety of the addition of sitagliptin to treatment of youth with type 2 diabetes and inadequate glycemic control on metformin without or with insulin

MY Jalaludin, A Deeb, P Zeitler, R Garcia… - Pediatric …, 2022 - Wiley Online Library
Objective To assess the efficacy and safety of sitagliptin in youth with type 2 diabetes (T2D)
inadequately controlled with metformin±insulin. Study Design Data were pooled from two 54 …

[HTML][HTML] Unmet needs in the treatment of childhood type 2 diabetes: a narrative review

W Tamborlane, N Shehadeh - Advances in Therapy, 2023 - Springer
Abstract Type 2 diabetes (T2D) in youth is a global health concern characterized by an
increasing incidence and prevalence, especially among disadvantaged socioeconomic …

[HTML][HTML] Complications and treatment of early-onset type 2 diabetes

F Soheilipour, NA Kasbi, M Imankhan… - International journal of …, 2023 - ncbi.nlm.nih.gov
Methods The literature search was conducted in the PubMed database to identify all
relevant original English articles published from the beginning of 2018 until January 2023 …

[HTML][HTML] Association between sitagliptin plus vitamin D3 (VIDPP-4i) use and clinical remission in patients with new-onset type 1 diabetes: a retrospective case-control …

MM Pinheiro, FMM Pinheiro, MM Arruda… - … of endocrinology and …, 2023 - SciELO Brasil
Objective: The occurrence of partial remission (honeymoon phase) in type 1 diabetes (T1D)
has been associated with a reduced risk of chronic microvascular complications of diabetes …

[HTML][HTML] Rising tide: The global surge of type 2 diabetes in children and adolescents demands action now

JM Pappachan, CJ Fernandez… - World Journal of …, 2024 - ncbi.nlm.nih.gov
Childhood-onset obesity has emerged as a major public healthcare challenge across the
globe, fueled by an obesogenic environment and influenced by both genetic and epigenetic …

The effects of incretin‐based therapies on weight reduction and metabolic parameters in children with obesity: A systematic review and meta‐analysis

JY Wang, JW Kang, CY Wu, TR Peng, LM Liao… - Obesity …, 2024 - Wiley Online Library
Background Growing evidence indicates that incretin‐based therapies (IBTs), glucagon‐like
peptide‐1 receptor agonists (GLP‐1 RAs), and dipeptidyl peptidase‐4 inhibitors (DPP4is) …