ISPAD Clinical Practice Consensus Guidelines 2022: Type 2 diabetes in children and adolescents
Since the 2018 ISPAD guidelines on this topic, follow‐up of large cohorts from around the
globe have continued informing the current incidence and prevalence of co‐morbidities and …
globe have continued informing the current incidence and prevalence of co‐morbidities and …
Efficacy and safety of the SGLT2 inhibitor empagliflozin versus placebo and the DPP-4 inhibitor linagliptin versus placebo in young people with type 2 diabetes …
LM Laffel, T Danne, GJ Klingensmith… - The lancet Diabetes & …, 2023 - thelancet.com
Background The incidence of type 2 diabetes in young people is increasing, but treatments
remain limited. We aimed to assess the efficacy and safety of an empagliflozin dosing …
remain limited. We aimed to assess the efficacy and safety of an empagliflozin dosing …
Childhood Obesity, Diabetes, and Cardiovascular Disease Risk
M Salama, B Balagopal, I Fennoy… - The Journal of Clinical …, 2023 - academic.oup.com
This mini-review aims to briefly summarize the pathophysiology of childhood obesity, type 2
diabetes mellitus (T2DM), and cardiovascular disease (CVD) risk in children and …
diabetes mellitus (T2DM), and cardiovascular disease (CVD) risk in children and …
Dapagliflozin or saxagliptin in pediatric type 2 diabetes
N Shehadeh, T Barrett, P Galassetti, C Karlsson… - NEJM …, 2023 - evidence.nejm.org
Background Incidence of type 2 diabetes (T2D) in children and adolescents is increasing,
but treatment options are limited. Methods This was a 26-week, phase 3 trial with a 26-week …
but treatment options are limited. Methods This was a 26-week, phase 3 trial with a 26-week …
Efficacy and safety of the addition of sitagliptin to treatment of youth with type 2 diabetes and inadequate glycemic control on metformin without or with insulin
MY Jalaludin, A Deeb, P Zeitler, R Garcia… - Pediatric …, 2022 - Wiley Online Library
Objective To assess the efficacy and safety of sitagliptin in youth with type 2 diabetes (T2D)
inadequately controlled with metformin±insulin. Study Design Data were pooled from two 54 …
inadequately controlled with metformin±insulin. Study Design Data were pooled from two 54 …
[HTML][HTML] Unmet needs in the treatment of childhood type 2 diabetes: a narrative review
W Tamborlane, N Shehadeh - Advances in Therapy, 2023 - Springer
Abstract Type 2 diabetes (T2D) in youth is a global health concern characterized by an
increasing incidence and prevalence, especially among disadvantaged socioeconomic …
increasing incidence and prevalence, especially among disadvantaged socioeconomic …
[HTML][HTML] Complications and treatment of early-onset type 2 diabetes
Methods The literature search was conducted in the PubMed database to identify all
relevant original English articles published from the beginning of 2018 until January 2023 …
relevant original English articles published from the beginning of 2018 until January 2023 …
[HTML][HTML] Association between sitagliptin plus vitamin D3 (VIDPP-4i) use and clinical remission in patients with new-onset type 1 diabetes: a retrospective case-control …
MM Pinheiro, FMM Pinheiro, MM Arruda… - … of endocrinology and …, 2023 - SciELO Brasil
Objective: The occurrence of partial remission (honeymoon phase) in type 1 diabetes (T1D)
has been associated with a reduced risk of chronic microvascular complications of diabetes …
has been associated with a reduced risk of chronic microvascular complications of diabetes …
[HTML][HTML] Rising tide: The global surge of type 2 diabetes in children and adolescents demands action now
JM Pappachan, CJ Fernandez… - World Journal of …, 2024 - ncbi.nlm.nih.gov
Childhood-onset obesity has emerged as a major public healthcare challenge across the
globe, fueled by an obesogenic environment and influenced by both genetic and epigenetic …
globe, fueled by an obesogenic environment and influenced by both genetic and epigenetic …
The effects of incretin‐based therapies on weight reduction and metabolic parameters in children with obesity: A systematic review and meta‐analysis
JY Wang, JW Kang, CY Wu, TR Peng, LM Liao… - Obesity …, 2024 - Wiley Online Library
Background Growing evidence indicates that incretin‐based therapies (IBTs), glucagon‐like
peptide‐1 receptor agonists (GLP‐1 RAs), and dipeptidyl peptidase‐4 inhibitors (DPP4is) …
peptide‐1 receptor agonists (GLP‐1 RAs), and dipeptidyl peptidase‐4 inhibitors (DPP4is) …