Hesperidin, a bioflavonoid, is an abundant and inexpensive by‐product of Citrus cultivation.
A deficiency of this substance in the diet has been linked with abnormal capillary leakiness …

Background Nuclear factor erythroid 2-related factor (Nrf2), a stress-activated transcription
factor, has been documented to induce a defense mechanism against oxidative stress …

Nephrotoxicity is a very important complication of 5-fluorouracil (5-FU)–treated cancer
patients. Increased oxidative stress, kidney damage, and apoptosis play an important role in …

Nephrotoxicity is an important complication in cancer patients undergoing cisplatin therapy.
Oxidative stress, inflammation and apoptosis/necrosis are the major patho-mechanisms of …

Background CCl 4 is a well-established hepatotoxin inducing liver injury by producing free
radicals. Exposure to CCl 4 also induces acute and chronic renal injuries. The present study …

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, but at high dose it
leads to undesirable side effects, such as hepatotoxicity and nephrotoxicity. The present …

A series of polymethoxylated flavonoids has been isolated from orange peel, and their
inhibitory activity toward soybean 15-lipoxygenase was determined. The strongest inhibition …

The study determined the comparative antioxidant capacities of five similar
dihydrochalcones: phloretin, phloridzin, trilobatin, neohesperidin dihydrochalcone, and …

The present study was to evaluate the protective role of hesperidin (HDN) against iron-
induced hepatic and renal toxicity in rats. Administration of iron (30 mg/kg body weight) …

Pomelo (Citrus grandis L. Osbeck) is a native fruit of great economic importance in
Southeast Asia. To provide experimental evidence for the antioxidant and antihyperlipidemic …