Shuttling of specific proteins out of the nucleus is essential for the regulation of the cell cycle
and proliferation of both normal and malignant tissues. Dysregulation of this fundamental …

The intracellular location of a protein is crucial to its normal functioning in a cell. Cancer cells
utilize the normal processes of nuclear-cytoplasmic transport through the nuclear pore …

Background Selinexor, a selective inhibitor of nuclear export compound that blocks exportin
1 (XPO1) and forces nuclear accumulation and activation of tumor suppressor proteins …

Esophageal squamous cell carcinoma (ESCC) is prevalent worldwide and particularly
common in certain regions of Asia. Here we report the whole-exome or targeted deep …

Studies have demonstrated that noncoding RNAs play important roles in various types of
cancer; however, noncoding RNAs derived from regions of genomic alterations have rarely …

The nuclear export protein XPO1 is overexpressed in cancer, leading to the cytoplasmic
mislocalization of multiple tumor suppressor proteins. Existing XPO1-targeting agents lack …

Purpose This trial evaluated the safety, pharmacokinetics, pharmacodynamics, and efficacy
of selinexor (KPT-330), a novel, oral small-molecule inhibitor of exportin 1 (XPO1/CRM1) …

The key nuclear export protein CRM1/XPO1 may represent a promising novel therapeutic
target in human multiple myeloma (MM). Here we showed that chromosome region …

Purpose Selinexor, a first-in-class, oral, selective exportin 1 (XPO1) inhibitor, induces
apoptosis in cancer cells through nuclear retention of tumor suppressor proteins and the …

Background Current markers for prostate cancer, such as PSA lack specificity. Therefore,
novel biomarkers are needed. Unfortunately, the complexity of body fluids often hampers …