During pregnancy, the maternal uterus and fetus form a special microenvironment at the
maternal-fetal interface to support fetal development. Extravillous trophoblasts (EVTs) …

HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

The genetic factors associated with susceptibility or resistance to viral infections are likely to
involve a sophisticated array of immune response. These genetic elements may modulate …

Maternal-fetal immune-tolerance occurs throughout the whole gestational trimester, thus a
mother can accept a genetically distinct fetus without immunological aggressive behavior …

Human ES cells (hESC) exposed to bone morphogenic protein 4 (BMP4) in the absence of
FGF2 have become widely used for studying trophoblast development, but the soundness of …

HLA-G is a non-classical HLA class I molecule with immunomodulatory properties. It was
initially described at the maternal-fetal interface, and it was later found that this molecule …

Unlike their protein “roommates” and their nucleic acid “cousins," carbohydrates remain an
enigmatic arm of biology. The central reason for the difficulty in fully understanding how …

Human leukocyte antigen G (HLA-G) is a non-classical major histocompatibility complex
(MHC) class I molecule that, through interaction with its receptors, exerts important …

HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-
G coding region has been maintained during the evolution process, in which most of its …

Structural and functional variability of human leukocyte antigen (HLA) is the foundation for
competent adaptive immune responses against pathogen and tumor antigens as it assures …