Animal models of hemophilia
DE Sabatino, TC Nichols, E Merricks… - Progress in molecular …, 2012 - Elsevier
The X-linked bleeding disorder hemophilia is caused by mutations in coagulation factor VIII
(hemophilia A) or factor IX (hemophilia B). Unless prophylactic treatment is provided …
(hemophilia A) or factor IX (hemophilia B). Unless prophylactic treatment is provided …
Establishment of outgrowth endothelial cells from peripheral blood
J Martin-Ramirez, M Hofman, M Van Den Biggelaar… - Nature protocols, 2012 - nature.com
Blood outgrowth endothelial cells (BOECs) are important tools when investigating diagnostic
and therapeutic approaches for vascular disease. In this protocol, mononuclear cells are …
and therapeutic approaches for vascular disease. In this protocol, mononuclear cells are …
Gene therapy strategies for hemophilia: benefits versus risks
I Petrus, M Chuah… - The journal of gene …, 2010 - Wiley Online Library
Hemophilia is an inherited bleeding disorder caused by a deficiency of functional clotting
factors VIII or IX in the blood plasma. The drawbacks of the classical protein substitution …
factors VIII or IX in the blood plasma. The drawbacks of the classical protein substitution …
An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF
W Pos, JTB Crawley, R Fijnheer… - Blood, The Journal …, 2010 - ashpublications.org
In the majority of patients with acquired thrombotic thrombocytopenic purpura (TTP),
antibodies are directed toward the spacer domain of ADAMTS13. We have previously …
antibodies are directed toward the spacer domain of ADAMTS13. We have previously …
Proteomic screen identifies IGFBP7 as a novel component of endothelial cell-specific Weibel-Palade bodies
D Van Breevoort, EL van Agtmaal… - Journal of proteome …, 2012 - ACS Publications
Vascular endothelial cells contain unique storage organelles, designated Weibel-Palade
bodies (WPBs), that deliver inflammatory and hemostatic mediators to the vascular lumen in …
bodies (WPBs), that deliver inflammatory and hemostatic mediators to the vascular lumen in …
[HTML][HTML] von Willebrand factor binds to angiopoietin-2 within endothelial cells and after release from Weibel–Palade bodies
G Mobayen, K Smith, K Ediriwickrema… - Journal of Thrombosis …, 2023 - Elsevier
Abstract Background The von Willebrand factor (VWF) is a multimeric plasma glycoprotein
essential for hemostasis, inflammation, and angiogenesis. The majority of VWF is …
essential for hemostasis, inflammation, and angiogenesis. The majority of VWF is …
Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device
C Olgasi, C Borsotti, S Merlin, T Bergmann… - … Therapy Methods & …, 2021 - cell.com
Hemophilia A (HA) is a rare bleeding disorder caused by deficiency/dysfunction of the FVIII
protein. As current therapies based on frequent FVIII infusions are not a definitive cure, long …
protein. As current therapies based on frequent FVIII infusions are not a definitive cure, long …
[图书][B] Anthropologie und Ethik des Enhancements
JC Heilinger - 2010 - degruyter.com
Bibliographie Page 1 Bibliographie Agar, M./Reisinger, HS (2001): Using Trend Theory to
Explain Heroin Use Trends. In: Journal of Psychoactive Drugs 33 (3), 203–211. Agar, Nicholas …
Explain Heroin Use Trends. In: Journal of Psychoactive Drugs 33 (3), 203–211. Agar, Nicholas …
[HTML][HTML] Endothelial characteristics in healthy endothelial colony forming cells; generating a robust and valid ex vivo model for vascular disease
Background Endothelial colony forming cells (ECFCs) derived from peripheral blood can be
used to analyze the pathophysiology of vascular diseases ex vivo. However, heterogeneity …
used to analyze the pathophysiology of vascular diseases ex vivo. However, heterogeneity …
Characterization and visualization of murine coagulation factor VIII-producing cells in vivo
M Hayakawa, A Sakata, H Hayakawa, H Matsumoto… - Scientific Reports, 2021 - nature.com
Coagulation factors are produced from hepatocytes, whereas production of coagulation
factor VIII (FVIII) from primary tissues and cell species is still controversial. Here, we tried to …
factor VIII (FVIII) from primary tissues and cell species is still controversial. Here, we tried to …