Multifaceted role of PARP-1 in DNA repair and inflammation: pathological and therapeutic implications in cancer and non-cancer diseases
S Pazzaglia, C Pioli - Cells, 2019 - mdpi.com
PARP-1 (poly (ADP-ribose)-polymerase 1), mainly known for its protective role in DNA
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …
Pan-cancer analysis of PARP1 alterations as biomarkers in the prediction of immunotherapeutic effects and the association of its expression levels and …
X Zhang, Y Wang, C Qu, J Chen - Frontiers in immunology, 2021 - frontiersin.org
Background Poly (ADP-ribose) polymerases-1 (PARP1) alterations are associated with
PARP1 inhibitor resistance, regulating the function of Treg cells and PDL1 expression in …
PARP1 inhibitor resistance, regulating the function of Treg cells and PDL1 expression in …
The PARP inhibitor olaparib potentiates the effect of the DNA damaging agent doxorubicin in osteosarcoma
Background PARP1 facilitates the recovery of DNA-damaged cells by recruiting DNA
damage response molecules such as γH2AX and BRCA1/2, and plays a role in resistance to …
damage response molecules such as γH2AX and BRCA1/2, and plays a role in resistance to …
Identification of a histone family gene signature for predicting the prognosis of cervical cancer patients
X Li, R Tian, H Gao, Y Yang, BRG Williams… - Scientific reports, 2017 - nature.com
Heterogeneity in terms of tumor characteristics, prognosis, and survival among cancer
patients is an unsolved issue. Here, we systematically analyzed the aberrant expression …
patients is an unsolved issue. Here, we systematically analyzed the aberrant expression …
PARP‐1 regulates DNA repair factor availability
MJ Schiewer, AC Mandigo, N Gordon… - EMBO molecular …, 2018 - embopress.org
PARP‐1 holds major functions on chromatin, DNA damage repair and transcriptional
regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional …
regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional …
High poly (ADP-ribose) polymerase expression does relate to poor survival in solid cancers: A systematic review and meta-analysis
Simple Summary Poly (ADP-ribose) polymerases (PARPs) are DNA damage repair proteins
that are involved in various biological activities ranges from cell proliferation to cell death …
that are involved in various biological activities ranges from cell proliferation to cell death …
Predictive biomarkers of pathological response to neoadjuvant chemoradiotherapy for locally advanced soft tissue sarcomas
A Szumera-Ciećkiewicz, K Bobak, MJ Spałek, K Sokół… - Cancers, 2023 - mdpi.com
Simple Summary Soft tissue sarcomas (STS) are a large group of heterogeneous
mesenchymal neoplasms. There is no standard treatment for STS and locally advanced …
mesenchymal neoplasms. There is no standard treatment for STS and locally advanced …
SIRT6 is involved in the progression of ovarian carcinomas via β-catenin-mediated epithelial to mesenchymal transition
SIRT6 is involved in various cellular signaling pathways including those involved in
tumorigenesis in association with β-catenin. However, the role of SIRT6 in tumorigenesis …
tumorigenesis in association with β-catenin. However, the role of SIRT6 in tumorigenesis …
Inhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma
Background SIRT6 has diverse roles in cells, and the role of SIRT6 in tumorigenesis is
controversial. Considering the role of SIRT6 as an inducer of DNA damage repair, it might …
controversial. Considering the role of SIRT6 as an inducer of DNA damage repair, it might …
FAM83H is involved in stabilization of β-catenin and progression of osteosarcomas
Background FAM83H was initially identified as a protein essential for dental enamel
formation. Recent reports have shown that FAM83H is also involved in the progression of …
formation. Recent reports have shown that FAM83H is also involved in the progression of …