The mammalian ovary from genesis to revelation

MA Edson, AK Nagaraja, MM Matzuk - Endocrine reviews, 2009 - academic.oup.com
Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

The chemical biology of nitric oxide: implications in cellular signaling

DD Thomas, LA Ridnour, JS Isenberg… - Free Radical Biology …, 2008 - Elsevier
Nitric oxide (NO) has earned the reputation of being a signaling mediator with many diverse
and often opposing biological activities. The diversity in response to this simple diatomic …

Nitric oxide: cytotoxicity versus cytoprotection—how, why, when, and where?

KD Kröncke, K Fehsel, V Kolb-Bachofen - Nitric oxide, 1997 - Elsevier
Nitric oxide (NO) has been found to play an important role as a signal molecule in many
parts of the organism as well as a cytotoxic effector molecule of the nonspecific immune …

Liver receptor homolog 1 is essential for ovulation

R Duggavathi, DH Volle, C Mataki… - Genes & …, 2008 - genesdev.cshlp.org
Female fertility requires normal ovarian follicular growth and ovulation. The nuclear receptor
liver receptor homolog 1 has been implicated in processes as diverse as bile acid …

The role of nitric oxide in oocyte meiotic maturation and ovulation: meiotic abnormalities of endothelial nitric oxide synthase knock-out mouse oocytes

A Jablonka-Shariff, LM Olson - Endocrinology, 1998 - academic.oup.com
Evidence supports the involvement of nitric oxide (NO) in ovulation, steroidogenesis, and
atresia-related apoptosis. This study was designed to investigate the role of endothelial nitric …

A review of nitric oxide and oxidative stress in typical ovulatory women and in the pathogenesis of ovulatory dysfunction in PCOS

AO Awonuga, OG Camp, HM Abu-Soud - Reproductive Biology and …, 2023 - Springer
Polycystic ovary syndrome (PCOS) is a heterogeneous functional endocrine disorder
associated with a low-grade, chronic inflammatory state. Patients with PCOS present an …

Polycystic ovary syndrome and iron overload: biochemical link and underlying mechanisms with potential novel therapeutic avenues

M Mathew, S Sivaprakasam, JL Phy… - Bioscience …, 2023 - portlandpress.com
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder in women with
components of significant genetic predisposition and possibly multiple, but not yet clearly …

Methods of decreasing sebum production in the skin

S Bauman, NA Stasko - US Patent 8,591,876, 2013 - Google Patents
Provided herein are methods of using gaseous nitric oxide and/or at least one nitric oxide
source to or decrease sebum production in the skin of a subject. In some embodiments, the …

Design, synthesis, modeling studies and biological evaluation of pyrazole derivatives linked to oxime and nitrate moieties as nitric oxide donor selective COX-2 and …

WAA Fadaly, YAMM Elshaier, MTM Nemr… - Bioorganic …, 2023 - Elsevier
Two new series of pyrazole derivatives 10a-f and 11a-f with selective COX-2 inhibition
pharmacophore and oxime/nitrate moieties as NO donor moiety were designed, synthesized …

Nitric oxide and the ovary

C Tamanini, G Basini, F Grasselli… - Journal of Animal …, 2003 - academic.oup.com
Nitric oxide (NO) is synthesized from L-arginine by NO synthase (NOS), an enzyme with
three isoforms. Two of them, neuronal and endothelial (nNOS and eNOS, respectively), are …