Retinoic acid (RA) is a vitamin A-derived, non-peptidic, small lipophilic molecule that acts as
ligand for nuclear RA receptors (RARs), converting them from transcriptional repressors to …

Neuraxial patterning is a continuous process that extends over a protracted period of
development. During gastrulation a crude anteroposterior pattern, detectable by molecular …

Chromosome conformation capture data, particularly from high-throughput approaches such
as Hi-C, are typically very complex to analyse. Existing analysis tools are often single …

Regulation of gene expression in eukaryotes is an extremely complex process. In this
review, we break down several critical steps, emphasizing new data and techniques that …

Summary Serotonin (5-HT) neurons, the major components of the raphe nuclei, arise from
ventral hindbrain progenitors. Based on anatomical location and axonal projection, 5-HT …

The RNA-binding proteins PTBP1 and PTBP2 control programs of alternative splicing during
neuronal development. PTBP2 was found to maintain embryonic splicing patterns of many …

The vitamin A (retinol) metabolite, all-trans retinoic acid (RA), is a signaling molecule that
plays key roles in the development of the body plan and induces the differentiation of many …

Morphogenesis of mammalian facial processes requires coordination of cellular
proliferation, migration, and apoptosis to develop intricate features. Cleft lip and/or palate …

Retinoic acid (RA) signaling plays an important role during heart development in
establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and …

The genetic networks that govern vertebrate development are well studied, but how the
interactions of trans-acting factors with cis-regulatory modules (CRMs) are integrated into …