Hydroxyquinolines are heterocyclic compounds characterized by a moderate metal-binding
affinity. The interest in 8-hydroxyquinolines has grown exponentially in the last two decades …

Metals and metal compounds have been used in medicine for several thousands of years. In
this review we summarized the anti-cancer activities of the ten most active metals: arsenic …

Aroylhydrazone and thiosemicarbazone iron (Fe) chelators have potent antitumor activity.
The aim of the current study was to examine the antitumor effects and mechanisms of action …

Iron-chelation therapy has its origins in the treatment of iron-overload syndromes. For many
years, the standard for this purpose has been deferoxamine. Recently, considerable …

The novel chelators 2-acetylpyridine-4, 4-dimethyl-3-thiosemicarbazone (H Ap44mT) and di-
2-pyridylketone-4, 4-dimethyl-3-thiosemicarbazone (H Dp44mT) have been examined to …

Iron (Fe) is critical for proliferation, but its precise role in cell cycle progression remains
unclear. In this study, we examined the mechanisms involved by assessing the effects of Fe …

Significance: Under normal circumstances, cellular iron levels are tightly regulated due to
the potential toxic effects of this metal ion. There is evidence that tumors possess altered iron …

Newer and more potent therapies are urgently needed to effectively treat advanced cancers
that have developed resistance and metastasized. One such strategy is to target cancer cell …

This review focuses on advances and strategies in the use of iron chelators as anti-tumor
therapies. Although the development of iron chelators for human disease has focused …

Iron (Fe) is essential for cellular metabolism eg, DNA synthesis and its depletion causes
G1/S arrest and apoptosis. Considering this, Fe chelators have been shown to be effective …