Conceptualizing mental disorders as deviations from normative functioning

AF Marquand, SM Kia, M Zabihi, T Wolfers… - Molecular …, 2019 - nature.com
Normative models are a class of emerging statistical techniques useful for understanding the
heterogeneous biology underlying psychiatric disorders at the level of the individual …

Psychosis superspectrum I: Nosology, etiology, and lifespan development

KG Jonas, TD Cannon, AR Docherty, D Dwyer… - Molecular …, 2024 - nature.com
This review describes the Hierarchical Taxonomy of Psychopathology (HiTOP) model of
psychosis-related psychopathology, the psychosis superspectrum. The HiTOP psychosis …

Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

R Karlsson Linnér, TT Mallard, PB Barr… - Nature …, 2021 - nature.com
Behaviors and disorders related to self-regulation, such as substance use, antisocial
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …

Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

D Demontis, GB Walters, G Athanasiadis, R Walters… - Nature …, 2023 - nature.com
Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder
with a major genetic component. Here, we present a genome-wide association study meta …

A canonical trajectory of executive function maturation from adolescence to adulthood

B Tervo-Clemmens, FJ Calabro, AC Parr… - Nature …, 2023 - nature.com
Theories of human neurobehavioral development suggest executive functions mature from
childhood through adolescence, underlying adolescent risk-taking and the emergence of …

Linked dimensions of psychopathology and connectivity in functional brain networks

CH Xia, Z Ma, R Ciric, S Gu, RF Betzel… - Nature …, 2018 - nature.com
Neurobiological abnormalities associated with psychiatric disorders do not map well to
existing diagnostic categories. High co-morbidity suggests dimensional circuit-level …

Modular segregation of structural brain networks supports the development of executive function in youth

GL Baum, R Ciric, DR Roalf, RF Betzel, TM Moore… - Current Biology, 2017 - cell.com
The human brain is organized into large-scale functional modules that have been shown to
evolve in childhood and adolescence. However, it remains unknown whether the underlying …

Burden of environmental adversity associated with psychopathology, maturation, and brain behavior parameters in youths

RE Gur, TM Moore, AFG Rosen, R Barzilay… - JAMA …, 2019 - jamanetwork.com
Importance Low socioeconomic status (L-SES) and the experience of traumatic stressful
events (TSEs) are environmental factors implicated in behavioral deficits, abnormalities in …

The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth

TD Satterthwaite, JJ Connolly, K Ruparel, ME Calkins… - Neuroimage, 2016 - Elsevier
Abstract The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale study of child
development that combines neuroimaging, diverse clinical and cognitive phenotypes, and …

Common and dissociable mechanisms of executive system dysfunction across psychiatric disorders in youth

S Shanmugan, DH Wolf, ME Calkins… - American journal of …, 2016 - Am Psychiatric Assoc
Objective: Disruption of executive function is present in many neuropsychiatric disorders.
However, determining the specificity of executive dysfunction across these disorders is …