Reactive oxygen species (ROS) are small and highly reactive molecules that can oxidize
proteins, lipids and DNA. When tightly controlled, ROS serve as signaling molecules by …

Recent findings have significantly expanded our understanding of the regulation of actin-
depolymerizing factor (ADF)/cofilin proteins and the profound multifaceted impact that these …

Autophagy is an evolutionarily conserved physiological process of self-digestion by a cell to
adapt to various stresses, including starvation. Its molecular basis involves the concerted …

Neuronal autophagy is enhanced in many neurological conditions, such as cerebral
ischemia and traumatic brain injury, but its role in associated neuronal death is …

Neurodegenerative disorders affect a significant portion of the world's population leading to
either disability or death for almost 30 million individuals worldwide. One novel therapeutic …

Apoptosis, autophagy and necrosis are the three main types of programmed cell death. One
or more of these types of programmed cell death may take place in neurons leading to their …

While the number of patients diagnosed with neurodegenerative disorders like Alzheimer's
disease, amyotrophic lateral sclerosis, and Parkinson's disease is increasing, there are …

Abstract Hydrogen peroxide (H2O2) is an extremely reactive oxidoradical that is normally
produced as a by-product of the mitochondrial activity and also under several metabolic …

Neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), Alzheimer's
disease, and Parkinson's disease, are characterized by the progressive loss of neurons in …

Diabetic peripheral neuropathy (DPN) is a chronic complication of diabetes, and its neural
mechanisms underlying the pathogenesis remain unclear. Autophagy plays an important …