The activating interplay of thrombosis and inflammation (thromboinflammation) has been
established as a major underlying pathway, driving not only cardiovascular disease but also …

The discovery of a disintegrin-like and metalloproteinase with thrombospondin type 1 motif,
member 13 (ADAMTS13) revolutionized our approach to thrombotic thrombocytopenic …

Stroke is a leading cause of death and disability. The only therapy available is recombinant
tissue plasminogen activator, but side effects limit its use. Platelets play a crucial role during …

Fast and accurate diagnosis of stroke is crucial for the immediate application of the right
therapy to patients. However, rapid diagnosis is still a challenge since an ischemic stroke …

von Willebrand factor (VWF) levels are elevated and a disintegrin-like and metalloprotease
with thrombospondin type I repeats–13 (ADAMTS13) activity is decreased in both acute and …

The interaction between platelets and the vessel wall is mediated by various receptors and
adhesive proteins, of which von Willebrand factor (VWF) is the most prominent. The …

Endothelial activation, dysfunction and permeability during... : Current Opinion in
Hematology Endothelial activation, dysfunction and permeability during severe infections …

Deficiency of a disintegrin and metalloproteinase with a thrombospondin type 1 motif,
member 13 (ADAMTS13), a VWF-cleaving protease, is the key factor in the pathogenesis of …

Epidemiologic studies suggest that elevated VWF levels and reduced ADAMTS13 activity in
the plasma are risk factors for myocardial infarction. However, it remains unknown whether …

ADAMTS13, a metalloprotease, plays a pivotal role in preventing spontaneous
microvascular thrombosis by cleaving hyperactive ultra large von Willebrand factor …