Although cytosolic glutathione S-transferase (GST) enzymes occupy a key position in
biological detoxification processes, two of the most relevant human isoenzymes, GSTT1-1 …

Glutathione S-transferases (GSTs) catalyse reactions between glutathione and lipophilic
compounds with electrophilic centres, leading to neutralisation of toxic compounds …

Complex disease such as cancer results from interactions of multiple genetic and
environmental factors. Studying these factors singularly cannot explain the underlying …

Background. The presence or absence of glutathione S-transferase M1 gene (GSTM1) and
glutathione S-transferase T1 gene (GSTT1) polymorphisms, and their combined effects have …

Cigarette smoking has been identified as a risk factor for rectal cancer. Our investigation
evaluates associations between active and passive smoking and TP53, KRAS2, and BRAF …

PURPOSE: Sporadic colorectal cancer (CRC) is considered to be a multifactorial disease, in
which multiple exposures to endogenous factors interact with individual genetic background …

Glutathione S-transferases (GSTs) are enzymes which expressed in many tissues and play
important roles in neutralization of toxic compounds and protecting hosts against cancer …

The main purpose of this study was to perform a meta-analysis to assess the interaction
between smoking and nine genes (GSTM1, GSTT1, GSTP1, CYP1A1, NAT2, SULT1A1 …

Introduction GSTT1 status has been extensively studied as a colorectal cancer risk factor.
However, the results are inconsistent. To examine this controversy, we performed a meta …

Glutathione S-transferases (GSTs) are a large family of phase II detoxification enzymes that
are expressed in many tissues and play critical roles in protecting hosts against cancer. The …