Diosgenin: an updated pharmacological review and therapeutic perspectives

P Semwal, S Painuli, T Abu-Izneid… - Oxidative medicine …, 2022 - Wiley Online Library
Plants including Rhizoma polgonati, Smilax china, and Trigonella foenum-graecum contain
a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high …

[HTML][HTML] Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications

S Ijaz, J Iqbal, BA Abbasi, Z Ullah, T Yaseen… - Biomedicine & …, 2023 - Elsevier
Cancer is still the leading cause of death worldwide, burdening the global medical system.
Rosmarinic acid (RA) is among the first secondary metabolites discovered and it is a …

[HTML][HTML] Multi-target mechanisms of phytochemicals in Alzheimer's disease: Effects on oxidative stress, neuroinflammation and protein aggregation

J Sharifi-Rad, S Rapposelli, S Sestito… - Journal of Personalized …, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a tangle-shaped
accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The …

The role of tumour necrosis factor in neuroinflammation associated with Parkinson's disease and targeted therapies

R Amin, C Quispe, AO Docea, A Ydyrys… - Neurochemistry …, 2022 - Elsevier
Neurodegenerative disorders Parkinson's disease is a progressive neurodegenerative
disorder associated with neuroinflammatory responses that lead to the neurodegeneration …

[HTML][HTML] The Effects of Andrographis paniculata (Burm.F.) Wall. Ex Nees and Andrographolide on Neuroinflammation in the Treatment of Neurodegenerative …

F Bosco, S Ruga, R Citraro, A Leo, L Guarnieri… - Nutrients, 2023 - mdpi.com
Neurodegenerative diseases (NDs) affect millions of people worldwide, and to date,
Alzheimer's and Parkinson's diseases are the most common NDs. Of the many risk factors …

[HTML][HTML] Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

ES Ali, S Akter, S Ramproshad, B Mondal… - Cancer cell …, 2022 - Springer
MAPK (mitogen-activated protein kinase) or ERK (extracellular-signal-regulated kinase)
pathway is an important link in the transition from extracellular signals to intracellular …

Andrographolide attenuates short-term spatial and recognition memory impairment and neuroinflammation induced by a streptozotocin rat model of Alzheimer's …

LC Souza, MK Andrade, EM Azevedo, DC Ramos… - Neurotoxicity …, 2022 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder clinically manifested by a gradual
cognitive decline. Intracerebroventricular injection (ICV) of streptozotocin (STZ), a model of …

[HTML][HTML] Eryngium caeruleum: an update on ethnobotany, phytochemistry and biomedical applications

DA Konovalov, EA Cáceres, EA Shcherbakova… - Chinese medicine, 2022 - Springer
Background A biennial or perennial plant of the Apiaceae family, Eryngium caeruleum M.
Bieb. is traditionally used in medicine as an antitoxic, diuretic, digestive, anti-inflammatory …

[HTML][HTML] Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update

P Asgharian, C Quispe, J Herrera-Bravo… - Frontiers in …, 2022 - frontiersin.org
Neuropsychiatric diseases are a group of disorders that cause significant morbidity and
disability. The symptoms of psychiatric disorders include anxiety, depression, eating …

[HTML][HTML] Neuroprotective strategies for stroke by natural products: advances and perspectives

A Liu, J Hu, TS Yeh, C Wang, J Tang… - Current …, 2023 - ncbi.nlm.nih.gov
Cerebral ischemic stroke is a disease with high prevalence and incidence. Its management
focuses on rapid reperfusion with intravenous thrombolysis and endovascular …