[HTML][HTML] Therapeutic strategies of three-dimensional stem cell spheroids and organoids for tissue repair and regeneration
Abstract Three-dimensional (3D) stem cell culture systems have attracted considerable
attention as a way to better mimic the complex interactions between individual cells and the …
attention as a way to better mimic the complex interactions between individual cells and the …
Strategies for 3D bioprinting of spheroids: A comprehensive review
Biofabricated tissues have found numerous applications in tissue engineering and
regenerative medicine in addition to the promotion of disease modeling and drug …
regenerative medicine in addition to the promotion of disease modeling and drug …
Halfway between 2D and animal models: are 3D cultures the ideal tool to study cancer-microenvironment interactions?
An area that has come to be of tremendous interest in tumor research in the last decade is
the role of the microenvironment in the biology of neoplastic diseases. The tumor …
the role of the microenvironment in the biology of neoplastic diseases. The tumor …
Print me an organ! Why we are not there yet
Bioprinting offers a highly-automated and advanced manufacturing platform that facilitates
the deposition of bio-inks (living cells, biomaterials and growth factors) in a scalable and …
the deposition of bio-inks (living cells, biomaterials and growth factors) in a scalable and …
Could 3D models of cancer enhance drug screening?
Cancer is a multifaceted pathology, where cellular and acellular players interact to drive
cancer progression and, in the worst-case, metastasis. The current methods to investigate …
cancer progression and, in the worst-case, metastasis. The current methods to investigate …
Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture
A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …
provide similar metabolism, proliferation, and species concentration gradients to those found …
[HTML][HTML] 3D-3-culture: A tool to unveil macrophage plasticity in the tumour microenvironment
SP Rebelo, C Pinto, TR Martins, N Harrer, MF Estrada… - Biomaterials, 2018 - Elsevier
The tumour microenvironment (TME) shapes disease progression and influences
therapeutic response. Most aggressive solid tumours have high levels of myeloid cell …
therapeutic response. Most aggressive solid tumours have high levels of myeloid cell …
Emerging tumor-on-chips with electrochemical biosensors
Cancer, one of the most dangerous diseases with a high mortality rate, has attracted much
attention and interest. Advances in tissue engineering and microfluidics have led to the …
attention and interest. Advances in tissue engineering and microfluidics have led to the …
Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applications
MC Decarli, R Amaral, DP Dos Santos, LB Tofani… - …, 2021 - iopscience.iop.org
Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …
Comparative analysis of 3D bladder tumor spheroids obtained by forced floating and hanging drop methods for drug screening
RLF Amaral, M Miranda, PD Marcato… - Frontiers in …, 2017 - frontiersin.org
Introduction: Cell-based assays using three-dimensional (3D) cell cultures may reflect the
antitumor activity of compounds more accurately, since these models reproduce the tumor …
antitumor activity of compounds more accurately, since these models reproduce the tumor …