Machine learning approach to evaluate TdP risk of drugs using cardiac electrophysiological model including inter-individual variability
Introduction: Predicting ventricular arrhythmia Torsade de Pointes (TdP) caused by drug-
induced cardiotoxicity is essential in drug development. Several studies used single …
induced cardiotoxicity is essential in drug development. Several studies used single …
Considering population variability of electrophysiological models improves the in silico assessment of drug-induced torsadogenic risk
Abstract Background and Objective In silico tools are known to aid in drug cardiotoxicity
assessment. However, computational models do not usually consider electrophysiological …
assessment. However, computational models do not usually consider electrophysiological …
Action potential morphology accurately predicts proarrhythmic risk for drugs with potential to prolong cardiac repolarization
W Lee, B Ng, MM Mangala, MD Perry… - Circulation …, 2023 - Am Heart Assoc
BACKGROUND: Drug-induced or acquired long QT syndrome occurs as a result of the
unintended disruption of cardiac repolarization due to drugs that block cardiac ion channels …
unintended disruption of cardiac repolarization due to drugs that block cardiac ion channels …
[HTML][HTML] Combining pharmacokinetic and electrophysiological models for early prediction of drug-induced arrhythmogenicity
J Llopis-Lorente, S Baroudi, K Koloskoff… - Computer Methods and …, 2023 - Elsevier
Abstract Background and Objective In silico methods are gaining attention for predicting
drug-induced Torsade de Pointes (TdP) in different stages of drug development. However …
drug-induced Torsade de Pointes (TdP) in different stages of drug development. However …
Accelerating Digitalization in Healthcare with the InSilicoTrials Cloud-Based Platform: Four Use Cases
The use of in silico trials is expected to play an increasingly important role in the
development and regulatory evaluation of new medical products. Among the advantages …
development and regulatory evaluation of new medical products. Among the advantages …
From multiscale biophysics to digital twins of tissues and organs: future opportunities for in-silico pharmacology
MT Barros, M Paci, A Tervonen… - … Biological, and Multi …, 2024 - ieeexplore.ieee.org
With many advancements in in silico multiscale biology in recent years, the paramount
challenge is to translate the accumulated knowledge into exciting industry partnerships and …
challenge is to translate the accumulated knowledge into exciting industry partnerships and …
Assessment of Drug Proarrhythmicity Using Artificial Neural Networks With in silico Deterministic Model Outputs
As part of the Comprehensive in vitro Proarrhythmia Assay initiative, methodologies for
predicting the occurrence of drug-induced torsade de pointes via computer simulations have …
predicting the occurrence of drug-induced torsade de pointes via computer simulations have …
Application of convolutional neural networks using action potential shape for in-silico proarrhythmic risk assessment
This study proposes a convolutional neural network (CNN) model using action potential (AP)
shapes as input for proarrhythmic risk assessment, considering the hypothesis that machine …
shapes as input for proarrhythmic risk assessment, considering the hypothesis that machine …
Occurrence of early afterdepolarization under healthy or hypertrophic cardiomyopathy conditions in the human ventricular endocardial myocyte: In silico study using …
B Christophe - Toxicology and Applied Pharmacology, 2022 - Elsevier
The goal of the CiPA initiative (Comprehensive in vitro Proarrhythmia Assay) was to assess
a more accurate prediction of new drug candidate proarrhythmic severe liabilities such as …
a more accurate prediction of new drug candidate proarrhythmic severe liabilities such as …
[HTML][HTML] Insights from an electro-mechanical heart failure cell model: Role of SERCA enhancement on arrhythmogenesis and myocyte contraction
MT Mora, A Zaza, B Trenor - Computer Methods and Programs in …, 2023 - Elsevier
Background and objective Structural and electrical remodeling in heart failure predisposes
the heart to ventricular arrhythmias. Computer modeling approaches, used to complement …
the heart to ventricular arrhythmias. Computer modeling approaches, used to complement …