Fueled by developments in computational neuroscience, there has been increasing interest
in the underlying neurocomputational mechanisms of psychosis. One successful approach …

Hallucinations, perceptions in the absence of objectively identifiable stimuli, illustrate the
constructive nature of perception. Here, we highlight the role of prior beliefs as a critical …

Aberrant patterns of brain functional connectivity in the default mode network (DMN) have
been observed across different classes of substance use disorder (SUD) and are associated …

Background: Lysergic acid diethylamide (LSD) has agonist activity at various serotonin (5-
HT) and dopamine receptors. Despite the therapeutic and scientific interest in LSD, specific …

A considerable body of evidence has accumulated over recent years on the functions of the
default-mode network (DMN)–a set of brain regions whose activity is high when the mind is …

Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …

Importance Severe neuropsychiatric conditions, such as schizophrenia, affect distributed
neural computations. One candidate system profoundly altered in chronic schizophrenia …

Translating advances in neuroscience into benefits for patients with mental illness presents
enormous challenges because it involves both the most complex organ, the brain, and its …

Recent findings suggest the existence of a frontoparietal control system consisting of flexible
hubs that regulate distributed systems (eg, visual, limbic, motor) according to current task …

Schizophrenia is a devastating neuropsychiatric syndrome associated with distributed brain
dysconnectivity that may involve large-scale thalamo-cortical systems. Incomplete …