In 2004, 12.5 percent of births in the United States were preterm; that is, born at less than 37
completed weeks of gestation. This rate has increased steadily in the past decade. There …

There is no consensus on the optimal pCO2 levels in the newborn. We reviewed the effects
of hypercapnia and hypocapnia and existing carbon dioxide thresholds in neonates. A …

Permissive hypercapnia, a strategy allowing high Paco 2, is widely used by neonatologists
to minimize lung damage in ventilated very low birth weight (VLBW) infants. While …

Many advances in neonatology in the last several decades have allowed for the
resuscitation, support, and survival of more preterm infants. The mortality associated with …

The current bronchopulmonary dysplasia (BPD) is seen in infants born extremely premature,
with less severe respiratory distress syndrome (RDS) and who received prenatal steroids …

Lung injury in ventilated premature infants occurs primarily through the mechanism of
volutrauma, often due to the combination of high tidal volumes in association with a high end …

Persistent pulmonary hypertension of the newborn (PPHN) is characterized by severe
hypoxemia shortly after birth, absence of cyanotic congenital heart disease, marked …

BACKGROUND: Permissive hypercapnia is a lung-protection strategy. We sought to review
our current clinical practice for the range of permissive hypercapnia and identify the …

Induction of hypercapnia by breathing high concentrations of carbon dioxide (CO2) may
have beneficial effects on the pulmonary circulation. We tested the hypothesis that exposure …

Background The arterial partial pressure of carbon dioxide (PaCO 2) represents the balance
between CO 2 production and consumption. Abnormal increase or decrease in PaCO 2 can …