The nucleophilic addition of carbon nucleophiles to amides has traditionally been a difficult
task, both due to reactivity and selectivity problems. When successful, these processes …

Amides are a class of easily available compounds, and widely serve as versatile
intermediates in organic synthesis and medicinal chemistry. Amide-based transformations …

The tertiary amide is a ubiquitous functional group and plays an irreplaceable role in
medicinal chemistry. Its robust nature has meant—in the past—that selective manipulation of …

A new iridium‐catalyzed reductive Strecker reaction for the direct and efficient formation of α‐
amino nitrile products from a broad range of (hetero) aromatic and aliphatic tertiary amides …

A variety of inert tertiary amides have been successfully transformed into synthetically
important chiral propargylamines in high yields with good to excellent enantioselectivities …

Amines are an important class of compounds that constitute the major body of bioactive
natural products (alkaloids) and pharmaceuticals.[1] Amides are a class of easily available …

Amides are ubiquitous in the fine chemical, agrochemical and pharmaceutical industries, but
are rarely exploited as substrates for homologous amine synthesis. By virtue of their high …

A new iridium catalyzed reductive coupling reaction of Grignard reagents and tertiary
amides affording functionalised tertiary amine products via an efficient and technically …

Nucleophilic addition to amides has been recognized as a promising transformation for total
synthesis of complex alkaloids. Amides can accept two different organometallic reagents …

A new method for the synthesis of α‐branched amines by reductive functionalization of
tertiary carboxamides and lactams is described. The process relies on the efficient and …