▪ Abstract Successful viral replication requires not only the efficient production and spread of
progeny, but also evasion of host defense mechanisms that limit replication by killing …

Apoptosis is the process whereby individual cells of multicellular organisms undergo
systematic self-destruction in response to a wide variety of stimuli. Apoptosis is a genetically …

Although the cytotoxic effects of viruses are usually viewed in terms of pathogenicity, it is
possible to harness this activity for therapeutic purposes. Viral genomes are highly versatile …

Rapid advances are being made in the engineering of replication-competent viruses to treat
cancer. Adenovirus is a mildly pathogenic human virus that propagates prolifically in …

In the past decade, adenovirus vectors have generated tremendous interest, especially in
gene therapy applications. In the so-called 'first generation'adenovirus vectors, the …

Human adenoviruses (HAdV) are ubiquitous human pathogens that cause a significant
burden of respiratory, ocular, and gastrointestinal illnesses. Although HAdV infections are …

Cellular BCL-2-related proteins (cBCL-2s) function as regulators of programmed cell death
(apoptosis), in part by modulating the release of proapoptotic signaling molecules from …

Adenoviruses (Ads) are common opportunistic pathogens that are rarely associated with
severe clinical symptoms in healthy individuals. In contrast, in patients with compromised …

Efficient infection with adenovirus (Ad) vectors based on serotype 5 (Ad5) requires the
presence of coxsackievirus-adenovirus receptors (CAR) and αv integrins on cells. The …

Human adenoviruses (HAdV) are one of the most important pathogens detected in acute
respiratory diseases in pediatrics and immunocompromised patients. In 1953, Wallace …