C1q is a versatile innate immune molecule that serves as the initiation subcomponent of the
classical complement pathway. In addition, it is also a potent pattern recognition molecule …

C1q, the ligand recognition subcomponent of the classical complement pathway has
steadily been gaining recognition as a bridge between innate and adaptive immunity. C1q …

Splenic CD169+ macrophages are located in the marginal zone to efficiently capture blood-
borne pathogens. Here, we investigate the requirements for the induction of CD8+ T cell …

Allergic asthma is a chronic lung disease resulting from an inappropriate T helper (Th)-2
response to environmental antigens. Early tolerance induction is an attractive approach for …

Antigen presentation is no longer the exclusive domain of cells of hematopoietic origin.
Recent works have demonstrated that lymph node stromal cell (LNSC) populations, such as …

The complement system has long been known for its role in combating infections. More
recently the complement system is becoming increasingly appreciated for its role in …

Complement is a part of the innate immune system that contributes to first-line host defense.
It is also implicated in a number of human inflammatory conditions and has attracted interest …

The overpowering effect of trauma on the immune system is undisputed. Severe trauma is
characterized by systemic cytokine generation, activation and dysregulation of systemic …

Rodent models for arthritis implicate a role for complement in disease development and
progression. In humans, complement deposition has been observed in inflamed synovia of …

The complement system is a family of serum and cell surface proteins that recognize
pathogen-associated molecular patterns, altered-self ligands, and immune complexes …