Iron is an essential micronutrient for virtually all living cells. In infectious diseases, both
invading pathogens and mammalian cells including those of the immune system require iron …

The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …

Iron is an essential nutrient for bacterial growth, replication, and metabolism. Humans store
iron bound to various proteins such as hemoglobin, haptoglobin, transferrin, ferritin, and …

Conspectus This Account focuses on the coordination chemistry of the microbial iron
chelators called siderophores. The initial research (early 1970s) focused on simple analogs …

Treatment of tuberculosis (TB) remains challenging, with lengthy treatment durations and
complex drug regimens that are toxic and difficult to administer. Similar to the vast majority of …

Neutrophil gelatinase-associated lipocalin (NGAL), an essential component of the
antimicrobial innate immune system, is present in neutrophils and multiple other tissues. It …

Pseudomonas aeruginosa is the most common pathogen that persists in the cystic fibrosis
lungs. Bacteria such as P. aeruginosa secrete siderophores (iron‐chelating molecules) and …

Synthetic radionuclides, such as the transuranic actinides plutonium, americium, and
curium, present severe health threats as contaminants, and understanding the scope of the …

Bacterial pathogens use siderophores to obtain iron from the host in order to survive and
grow. The host defends against siderophore-mediated iron acquisition by producing …

During Escherichia coli urinary tract infections, cells in the human urinary tract release the
antimicrobial protein siderocalin (SCN; also known as lipocalin 2, neutrophil gelatinase …