PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD
Obesity is a worldwide epidemic that predisposes individuals to cardiometabolic
complications, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease …
complications, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease …
Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism
Certain members of the gut microbiota exhibit diurnal variations in relative abundance and
function to serve as non-canonical drivers of host circadian rhythms and metabolism. Also …
function to serve as non-canonical drivers of host circadian rhythms and metabolism. Also …
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function.
Here we show that high-fat diet (HFD)-induced obesity augments the numbers and function …
Here we show that high-fat diet (HFD)-induced obesity augments the numbers and function …
[HTML][HTML] High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
Obesity is an established risk factor for cancer in many tissues. In the mammalian intestine, a
pro-obesity high-fat diet (HFD) promotes regeneration and tumorigenesis by enhancing …
pro-obesity high-fat diet (HFD) promotes regeneration and tumorigenesis by enhancing …
Regulation of energy metabolism by long-chain fatty acids
MT Nakamura, BE Yudell, JJ Loor - Progress in lipid research, 2014 - Elsevier
In mammals, excess energy is stored primarily as triglycerides, which are mobilized when
energy demands arise. This review mainly focuses on the role of long chain fatty acids …
energy demands arise. This review mainly focuses on the role of long chain fatty acids …
Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity
Adipose tissue hypoxia and inflammation have been causally implicated in obesity-induced
insulin resistance. Here, we report that, early in the course of high-fat diet (HFD) feeding and …
insulin resistance. Here, we report that, early in the course of high-fat diet (HFD) feeding and …
Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance
K Ito, R Turcotte, J Cui, SE Zimmerman, S Pinho… - Science, 2016 - science.org
A single hematopoietic stem cell (HSC) is capable of reconstituting hematopoiesis and
maintaining homeostasis by balancing self-renewal and cell differentiation. The …
maintaining homeostasis by balancing self-renewal and cell differentiation. The …
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
Stem-cell function is an exquisitely regulated process. Thus far, the contribution of metabolic
cues to stem-cell function has not been well understood. Here we identify a previously …
cues to stem-cell function has not been well understood. Here we identify a previously …
[HTML][HTML] PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation
Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were
thought to serve as simple energy storing molecules. More recently it has been realized that …
thought to serve as simple energy storing molecules. More recently it has been realized that …
PPARs: fatty acid sensors controlling metabolism
L la Cour Poulsen, M Siersbæk, S Mandrup - Seminars in cell & …, 2012 - Elsevier
The peroxisome proliferator activated receptors (PPARs) are nuclear receptors that play key
roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation …
roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation …