No longer viewed as a metabolic waste product and cause of muscle fatigue, a
contemporary view incorporates the roles of lactate in metabolism, sensing and signaling in …

The skeletal muscle is a dynamic organ composed of contractile muscle fibers, connective
tissues, blood vessels and nerve endings. Its main function is to provide motility to the body …

Skeletal muscle relies on resident muscle stem cells (MuSCs) for growth and repair. Aging
and muscle diseases impair MuSC function, leading to stem cell exhaustion and …

Aging is accompanied by a loss of muscle mass and function, termed sarcopenia, which
causes numerous morbidities and economic burdens in human populations. Mechanisms …

Antibodies are essential to immune homeostasis due to their roles in neutralizing
pathogenic agents. However, failures in central and peripheral checkpoints that eliminate …

Organismal aging involves functional declines in both somatic and reproductive tissues.
Multiple strategies have been discovered to extend lifespan across species. However, how …

Adult stem cells maintain homeostasis and enable regeneration of most tissues.
Quiescence, proliferation, and differentiation of stem cells and their progenitors are tightly …

Molecular tools for analysing in vivo senescence | Nature Reviews Molecular Cell Biology Skip
to main content Thank you for visiting nature.com. You are using a browser version with limited …

Human aging is characterized by a gradual decline in physiological functions and an
increased susceptibility to various diseases. The complex mechanisms underlying human …

Calorie restriction (CR) and treatment with rapamycin (RM), an inhibitor of the mTORC1
growth-promoting signaling pathway, are known to slow aging and promote health from …