IsomiRs–the overlooked repertoire in the dynamic microRNAome
CT Neilsen, GJ Goodall, CP Bracken - Trends in genetics, 2012 - cell.com
The development of deep sequencing has enabled the identification of novel microRNAs
(miRNAs), leading to a growing appreciation for the fact that individual miRNAs can be …
(miRNAs), leading to a growing appreciation for the fact that individual miRNAs can be …
Regulation of miRNA strand selection: follow the leader?
HA Meijer, EM Smith, M Bushell - Biochemical Society …, 2014 - portlandpress.com
miRNA strand selection is the process that determines which of the two strands in a miRNA
duplex becomes the active strand that is incorporated into the RISC (RNA-induced silencing …
duplex becomes the active strand that is incorporated into the RISC (RNA-induced silencing …
5′ isomiR variation is of functional and evolutionary importance
We have sequenced miRNA libraries from human embryonic, neural and foetal
mesenchymal stem cells. We report that the majority of miRNA genes encode mature …
mesenchymal stem cells. We report that the majority of miRNA genes encode mature …
[HTML][HTML] The repertoire and features of human platelet microRNAs
H Plé, P Landry, A Benham, C Coarfa, PH Gunaratne… - PloS one, 2012 - journals.plos.org
Playing a central role in the maintenance of hemostasis as well as in thrombotic disorders,
platelets contain a relatively diverse messenger RNA (mRNA) transcriptome as well as …
platelets contain a relatively diverse messenger RNA (mRNA) transcriptome as well as …
[HTML][HTML] The microRNA biology of the mammalian nucleus
TC Roberts - Molecular Therapy-Nucleic Acids, 2014 - cell.com
MicroRNAs (miRNAs) are a class of genome-encoded small RNAs that are primarily
considered to be post-transcriptional negative regulators of gene expression acting in the …
considered to be post-transcriptional negative regulators of gene expression acting in the …
MicroRNA in teleost fish
TT Bizuayehu, I Babiak - Genome biology and evolution, 2014 - academic.oup.com
MicroRNAs (miRNAs) are transcriptional and posttranscriptional regulators involved in
nearly all known biological processes in distant eukaryotic clades. Their discovery and …
nearly all known biological processes in distant eukaryotic clades. Their discovery and …
Skeletal muscle‐enriched miRNAs are highly unstable in vivo and may be regulated in a Dicer‐independent manner
MicroRNAs (miRNAs) are small noncoding RNAs that control essential cellular processes.
For several decades, the molecular mechanisms underlying the functions and biogenesis of …
For several decades, the molecular mechanisms underlying the functions and biogenesis of …
Chronic atrial fibrillation increases microRNA-21 in human atrial myocytes decreasing L-type calcium current
A Barana, M Matamoros, P Dolz-Gaiton… - Circulation …, 2014 - Am Heart Assoc
Background—Atrial fibrillation is characterized by progressive atrial structural and electrical
changes (atrial remodeling) that favor arrhythmia recurrence and maintenance. Reduction of …
changes (atrial remodeling) that favor arrhythmia recurrence and maintenance. Reduction of …
[HTML][HTML] microRNAs as promising biomarkers of platelet activity in antiplatelet therapy monitoring
TL Krammer, M Mayr, M Hackl - International Journal of Molecular …, 2020 - mdpi.com
Given the high morbidity and mortality of cardiovascular diseases (CVDs), novel biomarkers
for platelet reactivity are urgently needed. Ischemic events in CVDs are causally linked to …
for platelet reactivity are urgently needed. Ischemic events in CVDs are causally linked to …
Next generation sequencing reveals microRNA isoforms in liver cirrhosis and hepatocellular carcinoma
A Wojcicka, M Swierniak, O Kornasiewicz… - The international journal …, 2014 - Elsevier
Hepatocellular carcinoma (HCC) represents the major histological subtype of liver cancer.
Tumorigenic changes in hepatic cells potentially result from aberrant expression of …
Tumorigenic changes in hepatic cells potentially result from aberrant expression of …