[HTML][HTML] The world of protein acetylation
Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
[HTML][HTML] Spotlight on protein N-terminal acetylation
N-terminal acetylation (Nt-acetylation) is a widespread protein modification among
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …
Targeting the N terminus for site-selective protein modification
CB Rosen, MB Francis - Nature chemical biology, 2017 - nature.com
The formation of well-defined protein bioconjugates is critical for many studies and
technologies in chemical biology. Tried-and-true methods for accomplishing this typically …
technologies in chemical biology. Tried-and-true methods for accomplishing this typically …
Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications
Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …
[HTML][HTML] Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases
Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
[HTML][HTML] Post-translational modifications of the protein termini
Post-translational modifications (PTM) involve enzyme-mediated covalent addition of
functional groups to proteins during or after synthesis. These modifications greatly increase …
functional groups to proteins during or after synthesis. These modifications greatly increase …
[HTML][HTML] Cotranslational sorting and processing of newly synthesized proteins in eukaryotes
M Gamerdinger, E Deuerling - Trends in biochemical sciences, 2023 - cell.com
Ribosomes interact with a variety of different protein biogenesis factors that guide newly
synthesized proteins to their native 3D shapes and cellular localization. Depending on the …
synthesized proteins to their native 3D shapes and cellular localization. Depending on the …
Post-translational modifications: regulators of neurodegenerative proteinopathies
One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …
Structure of native lens connexin 46/50 intercellular channels by cryo-EM
JB Myers, BG Haddad, SE O'Neill, DS Chorev… - Nature, 2018 - nature.com
Gap junctions establish direct pathways for cell-to-cell communication through the assembly
of twelve connexin subunits that form intercellular channels connecting neighbouring cells …
of twelve connexin subunits that form intercellular channels connecting neighbouring cells …
[HTML][HTML] Non-lysine ubiquitylation: Doing things differently
IR Kelsall - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
The post-translational modification of proteins with ubiquitin plays a central role in nearly all
aspects of eukaryotic biology. Historically, studies have focused on the conjugation of …
aspects of eukaryotic biology. Historically, studies have focused on the conjugation of …