The novel regulatory role of lnc RNA‐mi RNA‐mRNA axis in cardiovascular diseases

Y Huang - Journal of cellular and molecular medicine, 2018 - Wiley Online Library
Long noncoding RNA s (lnc RNA s) are RNA s longer than 200 nt in length that are
characterized by low levels of sequence conservation and expression; lnc RNA s modulate …

Aging, melatonin, and the pro-and anti-inflammatory networks

R Hardeland - International journal of molecular sciences, 2019 - mdpi.com
Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …

[HTML][HTML] Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19

J Ren, L Ding, D Zhang, G Shi, Q Xu, S Shen… - Theranostics, 2018 - ncbi.nlm.nih.gov
Long non-coding RNAs (lncRNAs) are involved in the pathology of various tumors, including
colorectal cancer (CRC). The crosstalk between carcinoma-associated fibroblasts (CAFs) …

The role of antioxidants in the interplay between oxidative stress and senescence

A Varesi, S Chirumbolo, LIM Campagnoli, E Pierella… - Antioxidants, 2022 - mdpi.com
Cellular senescence is an irreversible state of cell cycle arrest occurring in response to
stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and …

Targeting autophagy in aging and aging-related cardiovascular diseases

J Ren, Y Zhang - Trends in pharmacological sciences, 2018 - cell.com
Aging, an irreversible biological process, serves as an independent risk factor for chronic
disease including cancer, pulmonary, neurodegenerative, and cardiovascular diseases. In …

LncRNA HOXA-AS2 and its molecular mechanisms in human cancer

J Wang, Z Su, S Lu, W Fu, Z Liu, X Jiang, S Tai - Clinica chimica acta, 2018 - Elsevier
Long non-coding RNAs (lncRNAs), a novel class of noncoding RNAs, are commonly defined
as RNA molecules more than 200 nucleotides in length. Emerging research indicated that …

Protective role of melatonin in cardiac ischemia‐reperfusion injury: From pathogenesis to targeted therapy

H Zhou, Q Ma, P Zhu, J Ren, RJ Reiter… - Journal of pineal …, 2018 - Wiley Online Library
Acute myocardial infarction (MI) is a major cause of mortality and disability worldwide. In
patients with MI, the treatment option for reducing acute myocardial ischemic injury and …

H19 induces abdominal aortic aneurysm development and progression

DY Li, A Busch, H Jin, E Chernogubova, J Pelisek… - Circulation, 2018 - Am Heart Assoc
Background: Long noncoding RNAs have emerged as critical molecular regulators in
various biological processes and diseases. Here we sought to identify and functionally …

Melatonin alleviates vascular calcification and ageing through exosomal miR‐204/miR‐211 cluster in a paracrine manner

F Xu, JY Zhong, X Lin, SK Shan, B Guo… - Journal of pineal …, 2020 - Wiley Online Library
In the elderly with atherosclerosis, hypertension and diabetes, vascular calcification and
ageing are ubiquitous. Melatonin (MT) has been demonstrated to impact the cardiovascular …

Lnc RNA‐ATB: An indispensable cancer‐related long noncoding RNA

J Li, Z Li, W Zheng, X Li, Z Wang, Y Cui… - Cell proliferation, 2017 - Wiley Online Library
Abstract Objectives Long non‐coding RNAs (lncRNAs) are a group of non‐protein‐coding
RNA s that are greater than 200 nucleotides in length. Increasing evidence indicates that …