Skeletal disorders are among the leading debilitating factors affecting millions of people
worldwide. The use of stem cells for tissue repair has raised many promises in various …

Key Clinical Points Postmenopausal Osteoporosis Fragility fractures are very common
among postmenopausal women and are associated with increased morbidity, mortality, and …

Objective The objective is to formulate clinical practice guidelines for the pharmacological
management of osteoporosis in postmenopausal women. Conclusions Evidence from …

Key Clinical Points Postmenopausal Osteoporosis Fractures and osteoporosis are common,
particularly among older women, and hip fractures can be devastating. Treatment is …

Osteogenesis imperfecta (OI) is an inherited skeletal dysplasia characterized by bone
fragility and skeletal deformities. While the majority of cases are associated with pathogenic …

Bone turnover comprises two processes: the removal of old bone (resorption) and the laying
down of new bone (formation). N-terminal propeptide of type I procollagen (PINP) and C …

Objective The development of these guidelines is sponsored by the American Association of
Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology …

Background: The prevalence of osteoporosis is increasing in the United States. Purpose: To
evaluate low bone mass and osteoporosis treatments to prevent fractures. Data Sources …

ABSTRACT Abbreviations: AACE= American Association of Clinical Endocrinologists AFF=
atypical femur fracture ASBMR= American Society for Bone and Mineral Research BEL …

Background Unlike most chronic diseases, osteoporosis treatments are generally limited to
a single drug at a fixed dose and frequency. Nonetheless, no approved therapy is able to …