Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in
the liver of a patient with no history of alcohol abuse or other causes for secondary hepatic …

In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting
conditions or times of elevated energy demands is tightly regulated by neuroendocrine …

In parallel with the increasing prevalence of obesity and type 2 diabetes, sleep loss has
become common in modern societies. An increasing number of epidemiological studies …

Background: Sleep loss can modify energy intake and expenditure. Objective: To determine
whether sleep restriction attenuates the effect of a reduced-calorie diet on excess adiposity …

Abstract Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of
the renin–angiotensin system (RAS). Ang-(1–7) appears to play a central role in the RAS …

Abstract The NLRP3-IL-1β pathway plays an important role in adipose tissue (AT)-induced
inflammation and the development of obesity-associated comorbidities. We aimed to …

Ghrelin is the only known peripherally-derived orexigenic hormone, increasing appetite and
subsequent food intake. The ghrelinergic system has therefore received considerable …

Des-acyl ghrelin (DAG) is one of the three preproghrelin gene-encoded peptides. Compared
with ghrelin and obestatin, it has not received the attention it deserves. DAG has long been …

Context Human obesity is associated with increased circulating TNF-α, a proinflammatory
cytokine that induces hepatocyte cell death. Objective The potential beneficial effects of …